Results 41 to 50 of about 4,171,244 (302)
Tạp chí Khoa học và Công nghệDynamic flexible flow shop scheduling problems present a complex challenge, where new orders arrive stochastically during the current schedule; this uncertainty degrades schedule stability and resource utilization, highlighting the need for responsive ...
Huynh Nhat Trieu +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
An Effective Hybrid Genetic Algorithm for Hybrid Flow Shops with Sequence Dependent Setup Times and Processor Blocking [PDF]
Journal of Optimization in Industrial Engineering, 2009 Hybrid flow-shop or flexible flow shop problems have remained subject of intensive research over several years. Hybrid flow-shop problems overcome one of the limitations of the classical flow-shop model by allowing parallel processors at each stage of ...
doaj
Journal of Marine Science and Engineering, 2023 This paper investigates the multi-objective optimization problem in the production of offshore wind turbine steel pipe piles (OWTSPP). Considering the particularity of the steel pipe pile production process, it is divided into a flexible flow shop ...
Weihan Wang +4 more
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
A hybrid genetic approach to solve real make-to-order job shop scheduling problems [PDF]
, 1997 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro TecnologicoProcedimentos de busca local (ex. busca tabu) e algoritmos genéticos têm apresentado excelentes resultados em problemas clássicos de programação da produção em ambientes job ...
Candido, Marco Antonio Barbosa
core
NSGA-II simheuristic to solve a multi-objective flexible flow shop problem under stochastic machine breakdowns [PDF]
Journal of Project ManagementThis study proposes a simheuristic that hybridizes NSGA-II with Monte Carlo simulation to address a stochastic flexible flow shop problem featuring stochastic machine breakdowns.
Daniel Felipe Rodríguez-Espinosa +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Bubble formation at a flexible orifice with liquid cross-flow [PDF]
, 2004 In waste water treatment, biological processes for denitrification and nitrification are performed using oxidation ditches. In these reactors, the mixing and the aeration functions are dissociated: a bubble cloud is generated from flexible membrane ...
Hebrard, Gilles +3 more
core +1 more source
Complexity, 2022 In this study, a new mathematical model is presented to solve the flexible flow shop problem where transportation is reliable and there are constraints on intermediate buffers, budgets, and human resource learning effects. Firstly, the model is validated
Meysam Kazemi Esfeh +3 more
doaj +1 more source