Results 61 to 70 of about 4,171,244 (302)

Scheduling and batching in multi-site flexible flow shop environments [PDF]

2015 10th Iberian Conference on Information Systems and Technologies (CISTI), 2015
Global competition and the customers demand for customized products with shorter due dates, marked the introduction of the Extended Enterprise. In this Extended Manufacturing Environment (EME), lean, virtual, networked and distributed enterprises collaborate to respond to the market demands.
Santos, A. S., Madureira, A. M., Varela, Maria Leonilde Rocha, Putnik, Goran D., Kays, H. M. Emrul, Karim, A. N. M.   +5 more
openaire   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A New Lower Bound for Flexible Flow Shop Problem with Unrelated Parallel Machines

International Journal of Industrial Engineering and Production Research, 2014
Flexible flow shop scheduling problem (FFS) with unrelated parallel machines contains sequencing in flow shop where, at any stage, there exists one or more processors. The objective consists of minimizing the maximum completion time.
Nasim Nahavandi, Ebrahim Asadi Gangraj
doaj  

Flexible Symbiosis for Simulation Optimization in Production Scheduling: A Design Strategy for Adaptive Decision Support in Industry 5.0

Journal of Manufacturing and Materials Processing
In the rapidly evolving landscape of Industry 4.0 and the transition towards Industry 5.0, manufacturing systems face the challenge of adapting to dynamic, hyper-customized demands.
Mohaiad Elbasheer, Francesco Longo, Giovanni Mirabelli, Vittorio Solina   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Hybrid particle swarm optimization with Cauchy distribution for solving reentrant flexible flow shop with blocking constraint

KKU Engineering Journal, 2016
This paper addresses a problem of the two-stage flexible flow shop with reentrant and blocking constraints in Hard Disk Drive Manufacturing. This problem can be formulated as a deterministic FFS|stage=2,rcrc, block|Cmax problem.
Chatnugrob Sangsawang , Kanchana Sethanan   +1 more
doaj   +1 more source

Flow shop scheduling with inter-stage flexibility and blocking constraints

Computers & Operations Research
33 pages, 9 figures, submitted to "Computers & Operations Research" on Nov.
Gaia Nicosia, Andrea Pacifici, Ulrich Pferschy, Anna Russo Russo, Cecilia Salvatore   +4 more
openaire   +4 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source