Results 71 to 80 of about 196,547 (296)

Hybrid particle swarm optimization with Cauchy distribution for solving reentrant flexible flow shop with blocking constraint

open access: yesKKU Engineering Journal, 2016
This paper addresses a problem of the two-stage flexible flow shop with reentrant and blocking constraints in Hard Disk Drive Manufacturing. This problem can be formulated as a deterministic FFS|stage=2,rcrc, block|Cmax problem.
Chatnugrob Sangsawang   +1 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

A linear programming-based method for job shop scheduling [PDF]

open access: yes, 2012
We present a decomposition heuristic for a large class of job shop scheduling problems. This heuristic utilizes information from the linear programming formulation of the associated optimal timing problem to solve subproblems, can be used for any ...
A. P. J. Vepsalainen   +27 more
core   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

Improved discrete cuckoo‐search algorithm for mixed no‐idle permutation flow shop scheduling with consideration of energy consumption

open access: yesIET Collaborative Intelligent Manufacturing, 2021
The increasing number and types of industrial tasks require factories to be more flexible in production. An improved discrete cuckoo search algorithm (CSA) is proposed and used to optimise the mixed no‐idle permutation flow shop scheduling problem ...
Lingchong Zhong   +3 more
doaj   +1 more source

New efficient constructive heuristics for the hybrid flowshop to minimise makespan: A computational evaluation of heuristics [PDF]

open access: yes, 2018
This paper addresses the hybrid flow shop scheduling problem to minimise makespan, a well-known scheduling problem for which many constructive heuristics have been proposed in the literature. Nevertheless, the state of the art is not clear due to partial
Fernández-Viagas Escudero, Víctor   +2 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

A hybrid job-shop scheduling system [PDF]

open access: yes
The intention of the scheduling system developed at the Fraunhofer-Institute for Material Flow and Logistics is the support of a scheduler working in a job-shop.
Bayat-Sarmadi, Fahid   +3 more
core   +1 more source

A decomposition-based algorithm for flexible flow shop scheduling with stochastic processing times [PDF]

open access: yes, 2009
Best Student Paper Award of International Conference on Systems Engineering and Engineering Management 2009: Mr. Kai WangSince real manufacturing is dynamic and tends to suffer a wide range of uncertainties, research on production scheduling with ...
Choi, SH, Wang, K
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

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