Results 51 to 60 of about 2,937 (259)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Flexible Job Shop Scheduling with Job Rejection Policy and Rate-Modifying Preventive Maintenance Activities [PDF]

چشم‌انداز مدیریت صنعتی
Introduction: The flexible job shop system is one of the most widely used scheduling systems in production environments, consistently attracting researchers' attention due to its diverse applications.
Mohammad Ali Nikouei, Maghsoud Amiri, Seyyed Mohammad Ali Khatami Firouz Abadi, Mehdi Yazdani   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Reinforcement Learning Method for Solving Flexible Job Shop Scheduling Problem Based onDouble Layer Attention Network [PDF]

Jisuanji kexue
Flexible job shop scheduling problem(FJSP),as a variant of the job shop scheduling problem,has become an important research topic in the intelligent transformation of modern manufacturing industry due to the wide applicability.In recent years,deep ...
WANG Haoyan, LI Chongshou, LI Tianrui
doaj   +1 more source

The flexible job shop scheduling problem: A review

European Journal of Operational Research
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Dauzère-Pérès, Stéphane, Ding, Junwen, Shen, Liji, Tamssaouet, Karim   +3 more
openaire   +4 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Developing a Multiobjective Optimization Scheduling System for a Screw Manufacturer: A Refined Genetic Algorithm Approach

IEEE Access, 2014
Over time, the traditional single-objective job shop scheduling method has grown increasingly incapable of meeting the requirements of contemporary business models; thus, a multiobjective scheduling solution is required.
Tung-Kuan Liu, Yeh-Peng Chen, Jyh-Horng Chou   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

MODEL MULTIOBJECTIVE FLEXIBLE JOB SHOP SCHEDULING WITH BATCH PROCESS. [PDF]

International Journal of Advanced Research, 2018
To compete in business competition, each manufacture must be able to fulfill the consument demand precisely, While considering its lack of resource in terms of the amount of machine and the capacity of machine in processing each job. Scheduling is needed to assure the efficiency of the resource.
Ferdinan Rinaldo Tampubolon, Sawaluddin.
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source