Results 61 to 70 of about 2,035,483 (294)

Flexible Job Shop Scheduling with Job Rejection Policy and Rate-Modifying Preventive Maintenance Activities [PDF]

چشم‌انداز مدیریت صنعتی
Introduction: The flexible job shop system is one of the most widely used scheduling systems in production environments, consistently attracting researchers' attention due to its diverse applications.
Mohammad Ali Nikouei, Maghsoud Amiri, Seyyed Mohammad Ali Khatami Firouz Abadi, Mehdi Yazdani   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

An application of immune genetic algorithm for flexible job-shop scheduling problem

, 2010
The flexible job-shop scheduling problem (FJSP) is one of the most general and difficult of all traditional scheduling problem. The paper presents a novelty immune genetic algorithm (IGA) to solve the problem.
null Yunlong Zhu, Zhu YL(朱云龙), Ma J(马佳), Wang TR(王天然), null Jia Ma, null Tianran Wang   +5 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Developing a Multiobjective Optimization Scheduling System for a Screw Manufacturer: A Refined Genetic Algorithm Approach

IEEE Access, 2014
Over time, the traditional single-objective job shop scheduling method has grown increasingly incapable of meeting the requirements of contemporary business models; thus, a multiobjective scheduling solution is required.
Tung-Kuan Liu, Yeh-Peng Chen, Jyh-Horng Chou   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Application of lean scheduling and production control in non-repetitive manufacturing systems using intelligent agent decision support [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Lean Manufacturing (LM) is widely accepted as a world-class manufacturing paradigm, its currency and superiority are manifested in numerous recent success ...
Papadopoulou, Theopisti C
core   +6 more sources

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Escalonamento de tarefas job-shop realistas utilizando algoritmos genéticos em MATLAB [PDF]

, 2000
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Elétrica.Esta dissertação aborda o desenvolvimento e a implementação de um sistema para escalonamento de tarefas do tipo job-shop.
Beck, Felipe Luís
core