Results 41 to 50 of about 1,239 (261)

An Energy-Efficient Scheduling Approach for Flexible Job Shop Problem in an Internet of Manufacturing Things Environment

IEEE Access, 2019
This paper addresses the energy-efficient scheduling and real-time control of flexible job shop that requires rescheduling affected operations and updating the scheduling. For energy-efficient scheduling shop floor efficiently, we propose a metaheuristic
Songling Tian, Taiyong Wang, Lei Zhang, Xiaoqiang Wu   +3 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Flexible job-shop scheduling problem with parallel batch machines based on an enhanced multi-population genetic algorithm

Complex & Intelligent Systems
The flexible job-shop scheduling problem (FJSP) with parallel batch processing machine (PBM) is one of those long-standing issues that needs cutting-edge approaches. It is a recent extension of standard flexible job shop scheduling problems.
Lirui Xue, Shinan Zhao, Amin Mahmoudi, Mohammad Reza Feylizadeh   +3 more
doaj   +1 more source

Flexible job‐shop scheduling problem by genetic algorithm

Electrical Engineering in Japan, 2009
AbstractThe Flexible Job‐shop Scheduling Problem is an expansion of the traditional Job‐shop Scheduling Problem in which an operation can be processed by one or more machines. The purpose of this problem is to look for the smallest makespan. For that purpose, it is necessary to decide the optimal assignment of machines to operations and the order of ...
Ida, Kenichi, Oka, Kensaku
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Developing a Multiobjective Optimization Scheduling System for a Screw Manufacturer: A Refined Genetic Algorithm Approach

IEEE Access, 2014
Over time, the traditional single-objective job shop scheduling method has grown increasingly incapable of meeting the requirements of contemporary business models; thus, a multiobjective scheduling solution is required.
Tung-Kuan Liu, Yeh-Peng Chen, Jyh-Horng Chou   +2 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A benchmark dataset for multi-objective flexible job shop cell scheduling

Data in Brief
This data article presents a description of a benchmark dataset for the multi-objective flexible job shop scheduling problem in a cellular manufacturing environment. This problem considers intercellular moves, exceptional parts, sequence-dependent family
Derya Deliktaş, Ender Özcan, Ozden Ustun, Orhan Torkul   +3 more
doaj   +1 more source

A Hybrid EA for Reactive Flexible Job-shop Scheduling

Procedia Computer Science, 2012
AbstractIn this paper, we consider a reactive flexible job-shop scheduling problem (rFJSP) under uncertainty environment. The most existing reactive scheduling methods are characterized by least commitment strategies such as real-time dispatching that create partial schedules based on local information.
Lin Lin 0008, Mitsuo Gen, Yan Liang, Katsuhisa Ohno   +3 more
openaire   +1 more source