Results 51 to 60 of about 2,311,919 (246)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Developing a Multiobjective Optimization Scheduling System for a Screw Manufacturer: A Refined Genetic Algorithm Approach

IEEE Access, 2014
Over time, the traditional single-objective job shop scheduling method has grown increasingly incapable of meeting the requirements of contemporary business models; thus, a multiobjective scheduling solution is required.
Tung-Kuan Liu, Yeh-Peng Chen, Jyh-Horng Chou   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Modified Multi-Step Crossover Fusion (MSXF) In Solving Some Deterministic Job Shop Scheduling Problem (JSSP) [TS157.5. M214 2008 f rb]. [PDF]

, 2008
This thesis addresses the job shop scheduling problem (JSSP) with the objective of minimising the makespan value. Tesis ini membincangkan masalah penskedulan kerja kedaian (JSSP) dengan objektif untuk meminimumkan masa ...
Omar, Mahanim
core   +1 more source

A benchmark dataset for multi-objective flexible job shop cell scheduling

Data in Brief
This data article presents a description of a benchmark dataset for the multi-objective flexible job shop scheduling problem in a cellular manufacturing environment. This problem considers intercellular moves, exceptional parts, sequence-dependent family
Derya Deliktaş, Ender Özcan, Ozden Ustun, Orhan Torkul   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Hybrid EA for Reactive Flexible Job-shop Scheduling

Procedia Computer Science, 2012
AbstractIn this paper, we consider a reactive flexible job-shop scheduling problem (rFJSP) under uncertainty environment. The most existing reactive scheduling methods are characterized by least commitment strategies such as real-time dispatching that create partial schedules based on local information.
Lin Lin 0008, Mitsuo Gen, Yan Liang, Katsuhisa Ohno   +3 more
openaire   +2 more sources

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source