Results 21 to 30 of about 69,382 (268)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A high-pressure isostatic lamination technique to fabricate versatile carbon electrode-based perovskite solar cells

Communications Materials
Perovskite solar cells (PSCs) with evaporated gold (Au) electrodes have shown great efficiencies, but the maturity of the technology demands low-cost and scalable alternatives to progress towards commercialisation.
Luke J. Sutherland, Juan Benitez-Rodriguez, Doojin Vak, Shiqin Yan, Narendra Pai, Jacek Jasieniak, Mei Gao, George P. Simon, Hasitha C. Weerasinghe   +8 more
doaj   +1 more source

Recent Advances in Selective Laser Melting of Cobalt-Free Eutectic High-Entropy Alloys: Design, Microstructure, and Performance Control

Micromachines
With the strategic shift toward reducing reliance on critical raw materials, Cobalt-free eutectic high-entropy alloys (EHEAs) have emerged as a pivotal frontier for high-performance structural applications.
Xiaojun Tan, Xuyun Peng, Wei Tan, Jian Huang, Chaojun Ding, Yushan Yang, Jieshun Yang, Haitao Chen, Liang Guo, Qingmao Zhang   +9 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

High performance soft magnetic composites with optimized Fe3O4 coating layer using rotary reactor-based sputtering

Materials & Design
Soft magnetic composites with low power loss and high magnetic permeability are essential for energy-efficient and high-performance devices, as their applications have rapidly expanded.
Yongheum Choi, Yujin Kim, Saena Min, Dohun Kwon, Min-Woo Lee, Hwi-Jun Kim, Tae Joo Park, Young Min Park   +7 more
doaj   +1 more source

An Experimental Study of Micro-Dimpled Texture in Friction Control under Dry and Lubricated Conditions

Micromachines, 2021
Friction control is a vital technology for reaching sustainable development goals, and surface texturing is one of the most effective and efficient techniques for friction reduction.
Yuan Wei, Jesus Resendiz, Robert Tomkowski, Xu Liu   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Powering the Future: Opportunities and Obstacles in Lead‐Halide Inorganic Perovskite Solar Cells

Advanced Science
Efficiency, stability, and cost are crucial considerations in the development of photovoltaic technology for commercialization. Perovskite solar cells (PSCs) are a promising third‐generation photovoltaic technology due to their high efficiency and low ...
Narendra Pai, Dechan Angmo
doaj   +1 more source

Variable Time-Step Physics Engine with Continuous Compliance Contact Model for Optimal Robotic Grinding Trajectory Planning

Sensors
In the transition from virtual environments to real-world applications, the role of physics engines is crucial for accurately emulating and representing systems.
Yongcan Zhou, Yang Pan, Junpeng Chen, Tianjian Lei   +3 more
doaj   +1 more source

Identifying human body states by using a flexible integrated sensor

npj Flexible Electronics, 2020
Flexible sensors are required to be lightweight, compatible with the skin, sufficiently sensitive, and easily integrated to extract various kinds of body vital signs during continuous healthcare monitoring in daily life.
Ying Jin, Guoning Chen, Kete Lao, Songhui Li, Yong Lu, Yufeng Gan, Zhundong Li, Jiajia Hu, Jingcheng Huang, Jinxiu Wen, Honggui Deng, Min Yang, Zhiming Chen, Xiaoyan Hu, Baowen Liang, Jianyi Luo   +15 more
doaj   +1 more source