Results 31 to 40 of about 69,382 (268)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Manufacturing flexibility: Measures and relationships [PDF]

European Journal of Operational Research, 1999
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Rodney P. Parker, Andrew Wirth
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Statistical Analysis-Based Prediction Model for Fatigue Characteristics in Lap Joints Considering Weld Geometry, Including Gaps

Metals
Automotive chassis components, constructed as lap joints and produced by gas metal arc welding (GMAW), require fatigue durability. The fatigue properties of the weld in a lap joint are largely determined by weld geometry factors.
Dong-Yoon Kim, Jiyoung Yu
doaj   +1 more source

Flexible manufacturing systems for mass customisation manufacturing

International Journal of Mass Customisation, 2006
This paper presents innovative approaches in realising and exercising mass customisation in theoretical and practical applications. Strategies of generalised production line platform and modularisation are explored to support dynamic reconfigurations of mass customisation.
Guixiu Qiao, Roberto F. Lu, Charles R. McLean   +2 more
openaire   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Vision-Based Online Molten Pool Image Acquisition and Assessment for Quality Monitoring in Gas–Metal Arc Welding

Applied Sciences
In gas–metal arc welding (GMAW), the welding quality is influenced by various factors, including the welding conditions and external environment. Achieving a high welding quality requires careful observation and control. Welding monitoring is crucial for
Gwang-Gook Kim, Young-Min Kim, Dong-Yoon Kim, Jong-Kyu Park, Junhong Park, Jiyoung Yu   +5 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Salinity Sensor Using a Tapered Polarization-Maintaining Fiber-Based Sagnac Loop in a Fiber Ring Laser with Support Vector Regression for Improved Accuracy

Sensors
This paper proposes and experimentally demonstrates a fiber ring laser (FRL) salinity sensing system based on a Sagnac loop (SL) formed by a tapered polarization-maintaining fiber (TPMF).
Weihao Lin, Zihan Huang, Keyu Cai, Mingkun Zhang, Renan Xu, Yuhui Liu   +5 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source