Results 61 to 70 of about 37,321 (250)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Sensing Mechanisms of Flexible Pressure Sensors

open access: yesHighlights in Science, Engineering and Technology, 2023
In the first segment of this project, the merits of the flexible capacitive pressure sensor will be described. These benefits encompass lower power consumption, less signal drift, greater response repeatability, and others. However, as ductile materials are incompressible, the device's sensitivity won't be very good without adopting structures.
openaire   +1 more source

Force-Sensitive Interface Engineering in Flexible Pressure Sensors: A Review

open access: yesSensors, 2022
Flexible pressure sensors have received extensive attention in recent years due to their great importance in intelligent electronic devices. In order to improve the sensing performance of flexible pressure sensors, researchers are committed to making ...
Guojun Tai   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Research Progresses in Microstructure Designs of Flexible Pressure Sensors

open access: yesPolymers, 2022
Flexible electronic technology is one of the research hotspots, and numerous wearable devices have been widely used in our daily life. As an important part of wearable devices, flexible sensors can effectively detect various stimuli related to specific environments or biological species, having a very bright development prospect.
Hao Huang   +9 more
openaire   +2 more sources

Sense-based user interface platform for behavioral pattern analysis of young children

open access: yesMicro and Nano Systems Letters, 2023
This paper presents a system integration of a sense-based user interface (SUI) platform, comprised of flexible pressure and humidity sensor arrays with a commercial inertial measurement unit (IMU), to analyze behavioral patterns of young children.
Sangmin Lee   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Flexible polydimethylsiloxane pressure sensor with micro-pyramid structures and embedded silver nanowires: A novel application in urinary flow measurement

open access: yesNanotechnology and Precision Engineering
Flexible pressure sensors are lightweight and highly sensitive, making them suitable for use in small portable devices to achieve precise measurements of tiny forces.
Ben-Song Wang   +6 more
doaj   +1 more source

Flexible sensor matrix film-based wearable plantar pressure force measurement and analysis system.

open access: yesPLoS ONE, 2020
Plantar pressure force data derived from gait and posture are commonly used as health indicators for foot diagnosis, injury prevention, and rehabilitation.
Shumi Zhao   +4 more
doaj   +1 more source

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