Results 71 to 80 of about 1,923,601 (243)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Highly Sensitive NiO Flexible Temperature Sensor Prepared by Low-Temperature Sintering Electrohydrodynamic Direct Writing

Micromachines
Flexible temperature sensors have diverse applications and a great potential in the field of temperature monitoring, including healthcare, smart homes and the automotive industry.
Ting Wang, Xianruo Du, Gaofeng Zheng, Zhiyuan Xue, Junlin Zhang, Huatan Chen, Libo Gao, Wenwang Li, Xiang Wang, Yifang Liu, Jiaxin Jiang   +10 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Thin and Flexible Position Sensor

Journal of Robotics and Mechatronics, 1990
An artificial sensitive skin will be necessary for an intelligent robot in the near future. The sensor we propose is one step toward realizing such a sensitive skin for a robot. The sensor outputs an area of contact and its center and has the following features.
Makoto Shimojo, Masatoshi Ishikawa
openaire   +2 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Innovative Mobile Manipulator Solution for Modern Flexible Manufacturing Processes [PDF]

, 2019
Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.There is a paradigm shift in current manufacturing needs that is causing a change from the current mass-production-based approach to a mass customization approach where ...
Jose Luis Outón, Sierra, Basilio, Esnaola, Urko, Héctor Herrero, Urko Esnaola, Basilio Sierra, Outón, Jose Luis, Villaverde, Iván, Herrero, Héctor, Iván Villaverde   +9 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nitrate Pollution Mapping for Reservoirs Using Flexible Sensors Integrated with Underwater Robot [PDF]

Water pollution monitoring is crucial for environmental protection, playing a key role in safeguarding ecosystems, protecting public health and promoting sustainable development. However, traditional methods face challenges related to accessibility, real-
Kadara, R. O., Paul, F., Markapudi, P. R., Manjakkal, L., Beg, M., See, C. H., Kerrouche, A.   +6 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source