Results 71 to 80 of about 36,296 (323)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Hybrid strategy of graphene/carbon nanotube hierarchical networks for highly sensitive, flexible wearable strain sensors

Scientific Reports, 2021
One-dimensional and two-dimensional materials are widely used to compose the conductive network atop soft substrate to form flexible strain sensors for several wearable electronic applications.
Yiyi Li, Qinqin Ai, Linna Mao, Junxiong Guo, Tianxun Gong, Yuan Lin, Guitai Wu, Wen Huang, Xiaosheng Zhang   +8 more
doaj   +1 more source

A Composite Flexible Sensor for Direct Ventricular Assist Device

Sensors, 2022
A direct ventricular assist device is one of the effective means to treat patients with heart failure; the key point of the problem is the flexible sensor that can measure the drive pressure and shape variable of the heart auxiliary device.
Zhong Yun, Kuibing Li, Hao Jiang, Xiaoyan Tang   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Structural Engineering for High‐Performance Flexible and Stretchable Strain Sensors [PDF]

Advanced Intelligent Systems, 2020
Structural engineering is proved to be effective in improving both measurement sensitivity and range for flexible and stretchable strain sensors. Herein, the latest advancements in structural engineering strategies are summarized for the improvement of sensing performances of flexible and stretchable strain sensors.
Xin Huang, Zhouping Yin, Hao Wu 0028
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Visual Strain Sensors Based on Fabry–Perot Structures for Structural Integrity Monitoring

Sensors
Strain sensors that can rapidly and efficiently detect strain distribution and magnitude are crucial for structural health monitoring and human–computer interactions.
Qingyuan Chen, Furong Liu, Guofeng Xu, Boshuo Yin, Ming Liu, Yifei Xiong, Feiying Wang   +6 more
doaj   +1 more source

Measurement-Error Analysis of Fiber Bragg Grating Flexible Sensor for Displacement-Field Monitoring of Geotechnical Engineering

Sensors, 2022
Monitoring geotechnical structures and providing real-time early warning is a key measure to mitigate the impacts of disasters (slope slip, subsidence, dam deformation, bridge settlement, etc.). The fiber Bragg grating (FBG) flexible sensor, developed by
Changbin Tian, Xiangxue Ma, Bo Peng, Xin Ma, Zhiyu Li   +4 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source