Results 171 to 180 of about 9,419 (308)

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Optimized Design of a Sub-Arc-Second Micro-Drive Rotary Mechanism Based on the Swarm Optimization Algorithm. [PDF]

Micromachines (Basel)
Zhang N, Wang D, Li K, Lv Z, Gui H, Yang Y, Yang M.   +6 more
europepmc   +1 more source

CD3ɛ Nanobody‐Engineered Extracellular Vesicles Driving In Vivo Generation of BiTE‐Secreting CAR‐Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Advanced Science, EarlyView.
HEK‐293T‐derived CD3ε Nb‐engineered EVs to generate dual‐targeting CAR‐T cells directly in vivo. These EVs selectively deliver CAR.BiTE transgenes into T cells and reprogramed to HLA‐G/PD‐L1‐targeting effector cells with enhanced memory and persistence.
Shi‐Wei Huang, Yu‐Chuan Lin, Chih‐Ming Pan, Yeh Chen, Ming‐You Shie, Cheng‐Yu Chen, Kai‐Wen Kan, Yi‐Wen Chen, Ming‐Chao Liu, Chung‐Chun Wu, Yu‐Ting Chiang, Huai‐Ping Ho, Chen‐Yu Lin, Pei‐Ying Lin, Yu‐Han Huang, Steffany Rusli, Wan‐Yu Mao, Pei‐Wen Huang, Sin‐Ting Wang, Wan‐Chen Tsai, Ya‐Hsu Chiu, Ting‐Hsun Lin, Wan‐Ling Chiang, Che‐Kai Chang, Zi‐Lun Lai, Mei‐Chih Chen, Shao‐Chih Chiu, Der‐Yang Cho   +27 more
wiley   +1 more source

Traceless Regulation of Genetic Circuitry

Advanced Science, EarlyView.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

Torsional Characteristics of Injection-Molded Hinges from Plastics and Glass Fiber-Reinforced Plastics. [PDF]

Polymers (Basel)
Uyen TMT, Nguyen VT, Vo XT, Minh PS, Dang HNL.   +4 more
europepmc   +1 more source

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Development and Test of a Novel High-Precision Inchworm Piezoelectric Motor. [PDF]

Micromachines (Basel)
Huang N, Yin J, Feng F, Zhang L, Luo Y, Gao J.   +5 more
europepmc   +1 more source

On the Dependency of the Electromechanical Response of Rotary MEMS/NEMS on Their Embedded Flexure Hinges' Geometry. [PDF]

Micromachines (Basel), 2023
Buzzin A, Giannini L, Bocchetta G, Notargiacomo A, Giovine E, Scorza A, Asquini R, de Cesare G, Belfiore NP.   +8 more
europepmc   +1 more source

Monolithic 3D Printing of Origami‐Inspired Soft Robotics from Sustainable Bio‐Based Resin

Advanced Science, EarlyView.
This work develops a photocurable, bio‐based resin from soybean oil for the monolithic fabrication of sustainable soft robots via Digital Light Processing. An origami‐inspired, vacuum‐actuated soft gripper is designed and fabricated, enabling reliable operation despite the material's lower elongation.
Ramin Montazeri, Hugo de Souza Oliveira, Xin Li, Qingchuan Song, Bastian E. Rapp, Dorothea Helmer, Edoardo Milana   +6 more
wiley   +1 more source

Random Vibration Evaluation and Optimization of a Flexible Positioning Platform Considering Power Spectral Density. [PDF]

Sensors (Basel)
Zhang L, Hu M, Yan H, Sun H, Zhang Z, Wu P.   +5 more
europepmc   +1 more source