Results 41 to 50 of about 81,279 (303)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Flight muscle size reductions and functional changes following long‐distance flight under variable humidity conditions in a migratory warbler

Physiological Reports, 2023
Bird flight muscle can lose as much as 20% of its mass during a migratory flight due to protein catabolism, and catabolism can be further exacerbated under dehydrating conditions.
Derrick J. E. Groom, Betsy Black, Jessica E. Deakin, Joely G. DeSimone, M. Collette Lauzau, Bradley P. Pedro, Chad R. Straight, Kimberly P. Unger, Mark S. Miller, Alexander R. Gerson   +9 more
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Capacity management based on the integration of dynamic airspace configuration and flight centric ATC solutions using complexity [PDF]

, 2020
This paper presents a new capacity management concept where Dynamic Airspace Configuration (DAC) and Flight Centric ATC (FCA) are dynamically applied together during the Air Traffic Flow and Capacity Management (ATFCM) pretactical phase.
Melgosa Farrés, Marc, Terzioski, Predrag, Vidosavljevic, Andrija, Olivella, Pol, Zerrouki, Leïla   +4 more
core   +1 more source

Falling Victim to Wasps in the Air: A Fate Driven by Prey Flight Morphology? [PDF]

PLoS ONE, 2016
In prey-predator systems where the interacting individuals are both fliers, the flight performance of both participants heavily influences the probability of success of the predator (the prey is captured) and of the prey (the predator is avoided).
Yolanda Ballesteros, Carlo Polidori, José Tormos, Laura Baños-Picón, Josep D Asís   +4 more
doaj   +1 more source

Shaft Capacity of Continuous Flight Auger Piles in Sand [PDF]

Journal of Geotechnical and Geoenvironmental Engineering, 2009
This paper presents the results of a series of field experiments performed to study the development of shaft resistance on continuous flight auger piles installed in sand. The test piles were instrumented in order to separate the shaft and base resistance, and to allow the determination of the distribution of shaft resistance along the pile shaft.
K. G. Gavin, D. Cadogan, P. Casey
openaire   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Population Dynamics and Biological Control of Leucoptera malifoliella in Apple Orchards in Hebei Province, China

Insects
Leucoptera malifoliella has become a severe leaf-mining pest in Chinese apple orchards, especially under expanding organic and green cultivation practices, with effective management hindered by insufficient contemporary ecological data. To fill this gap,
Jia-Qiang Zhao, Hong-Wei Zhang, Qi Gao, Sheng-Ping Zhang, Shi-Hang Zhao, Jian-Ming Li, Han Chang, Zhao-Hui Yang, Guo-Liang Xu   +8 more
doaj   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source