Results 41 to 50 of about 54,794 (263)

Robust Trajectory Optimization of a Ski Jumper for Uncertainty Influence and Safety Quantification

Proceedings, 2018
This paper deals with the development of a robust optimal control framework for a previously developed multi-body ski jumper simulation model by the authors.
Patrick Piprek, Florian Holzapfel
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Chemical Mechanisms and Their Applications in the Goddard Earth Observing System (GEOS) Earth System Model

Journal of Advances in Modeling Earth Systems, 2017
NASA's Goddard Earth Observing System (GEOS) Earth System Model (ESM) is a modular, general circulation model (GCM), and data assimilation system (DAS) that is used to simulate and study the coupled dynamics, physics, chemistry, and biology of our planet.
J. Eric Nielsen, Steven Pawson, Andrea Molod, Benjamin Auer, Arlindo M. da Silva, Anne R. Douglass, Bryan Duncan, Qing Liang, Michael Manyin, Luke D. Oman, William Putman, Susan E. Strahan, Krzysztof Wargan   +12 more
doaj   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Adaptive Fault–Tolerant Position Control of a Hexacopter Subject to an Unknown Motor Failure

International Journal of Applied Mathematics and Computer Science, 2018
This paper presents a fault tolerant position tracking controller for a hexarotor system. The proposed controller has a cascaded structure composed of a position and an attitude control loop.
Falconì Guillermo P., Angelov Jorg, Holzapfel Florian   +2 more
doaj   +1 more source

On the stabilization of leading-edge vortices with different reduced frequencies over finite-aspect-ratio pitch-up wings

AIP Advances, 2020
An implicit large-eddy simulation method is used to numerically simulate the flowfield around a finite-span rectangular wing in pitch motion. The effect of the reduced frequency (k) on the stability of the leading-edge vortex (LEV) is studied.
JiaoLong Zhang, Jun Hu, Yong Yu, HaiBin Xuan   +3 more
doaj   +1 more source

Performance Enhancement by Wing Sweep for High-Speed Dynamic Soaring

Aerospace, 2021
Dynamic soaring is a flight mode that uniquely enables high speeds without an engine. This is possible in a horizontal shear wind that comprises a thin layer and a large wind speed.
Gottfried Sachs, Benedikt Grüter, Haichao Hong   +2 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Attitude Estimation of Skis in Ski Jumping Using Low-Cost Inertial Measurement Units

Proceedings, 2018
This paper presents an approach to estimate the attitude of skis for an entire ski jump using wearable, MEMS-based, low-cost Inertial Measurement Units (IMUs). First of all, a kinematic attitude model based on rigid-body dynamics and a sensor error model
Xiang Fang, Christoph Göttlicher, Florian Holzapfel   +2 more
doaj   +1 more source