Results 51 to 60 of about 113,027 (258)

In-flight Performance of the IXPE Telescopes

The Astronomical Journal
Abstract We present a comprehensive characterization of the on-orbit imaging performance of the three telescopes on board the Imaging X-ray Polarimetry Explorer (IXPE). Each telescope comprises a Wolter-I mirror module assembly and a Gas Pixel Detector focal-plane detector unit.
Riccardo Ferrazzoli, Enrico Costa, Sergio Fabiani, Philip Kaaret, Stephen L. O’Dell, Brian D. Ramsey, Paolo Soffitta, Luca Baldini, Ronaldo Bellazzini, Alessandro Di Marco, Fabio La Monaca, Luca Latronico, Alberto Manfreda, Fabio Muleri, John Rankin, Carmelo Sgró, Stefano Silvestri, Martin C. Weisskopf   +17 more
openaire   +2 more sources

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Studies on the Relationship between Occupational Stress and Mental Health, Performance, and Job Satisfaction of Chinese Civil Aviation Pilots

Aerospace, 2023
This research work delves into the potential impact of occupational stress on the mental health, performance, and job satisfaction of civil aviation pilots.
Yanzeng Zhao, Yanlong Wang, Wei Guo, Lin Cheng, Jialu Tong, Ruipeng Ji, Yizhi Zhou, Ziyu Liu, Lijing Wang   +8 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Insect‐Inspired Drones: Adjusting the Flapping Kinetics of Insect‐Inspired Wings Improves Aerodynamic Performance

Advanced Intelligent Systems
Insects flap their wings through a highly specialized musculoskeletal system that allows the wings to rotate about three degrees of freedom. Consequently, the wingtip trajectory is adjustable in 3D, and accompanied with appropriate wing feathering (wing ...
Leeor Mordoch, Eyal Sabag, Gal Ribak, Bat‐El Pinchasik   +3 more
doaj   +1 more source

High-Fidelity CFD Investigation of the Aerodynamic Influence of Fairing Integration for Helicopter Electrification Systems [PDF]

INCAS Bulletin
The electrification of rotary-wing aircraft introduces new aerodynamic challenges associated with the integration of batteries, electric propulsion systems, and thermal management components within the helicopter fuselage.
Octavian-Mircea CRISAN, Alexandru PASULA, Ionut BUNESCU, Mihai-Vladut HOTHAZIE, Mihai-Victor PRICOP, Bogdan RUSU, Dumitru PEPELEA, Mihaita-Gilbert STOICAN   +7 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Thermal and Oxygen Flight Sensitivity in Ageing Drosophila melanogaster Flies: Links to Rapamycin-Induced Cell Size Changes

Biology, 2021
Ectotherms can become physiologically challenged when performing oxygen-demanding activities (e.g., flight) across differing environmental conditions, specifically temperature and oxygen levels.
Ewa Szlachcic, Marcin Czarnoleski
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source