Results 101 to 110 of about 3,164 (230)

A 3D ovarian cancer metastasis model using a decellularised peritoneal matrix to study therapy response. [PDF]

EBioMedicine
Gjerde CH, Kleinmanns K, Langer A, Ruiz de Garibay Ponce G, Rozmus E, Stangeland GN, Leitch C, Elnour R, Dongre HN, Berger C, Gultekin O, Forcados C, Stensland M, Nyman TA, Lehti K, Davidson B, Wälchli S, Gelebart P, Costea DE, Kotopoulis S, Bjørge L, McCormack E.   +21 more
europepmc   +1 more source

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Two Cases of Mediastinal Non-Seminomatous Germ Cell Tumor with Complete Resection by Robot-Assisted Thoracoscopic Surgery after Induction Chemotherapy: Techniques for Identification and Preservation of the Phrenic Nerve. [PDF]

Surg Case Rep
Nakamura R, Okuda K, Iguchi K, Hosokawa S, Hagui E, Chiba K, Tatematsu T, Yokota K.   +7 more
europepmc   +1 more source

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

Atoh1 is required for the formation of lateral line electroreceptors and hair cells, whereas FoxG1 represses an electrosensory fate. [PDF]

Elife
Minařík M, Campbell AS, Franěk R, Vazačová M, Havelka M, Gela D, Pšenička M, Baker CVH.   +7 more
europepmc   +1 more source

Evidence for adaptive explanations of semelparity in animals

Biological Reviews, EarlyView.
ABSTRACT Semelparity, the reproductive strategy of reproducing once, is widespread but uncommon in animals. Classes of models to explain the evolution of semelparity are based either on age structure and mortality schedules – demographic models in which high post‐reproductive mortality risk favours high reproductive effort and semelparity results from ...
Diana O. Fisher, Roberto Salguero‐Gómez   +1 more
wiley   +1 more source

What Counts as Educational Innovation in Clinical Anatomy?

Clinical Anatomy, EarlyView.
ABSTRACT Clinical anatomy has become a prominent setting for educational innovation because it links anatomical science with diagnostic imaging, procedural practice, surgery, simulation, and patient safety. However, the term innovation is used inconsistently.
Juan A. Sanchis‐Gimeno, Mathis Orellana‐Donoso, Juan José Valenzuela‐Fuenzalida   +2 more
wiley   +1 more source

Flipped online teaching of histology and embryology with design thinking: design, practice and reflection. [PDF]

BMC Med Educ
Guo Y, Wang X, Gao Y, Yin H, Ma Q, Chen T.   +5 more
europepmc   +1 more source

A Bio‐Based Chiroptical Overcrowded Alkene From Flavanone: Photoreactivity and Theoretical Investigation

Chemistry – A European Journal, EarlyView.
A sustainable route to photoresponsive molecular systems is achieved using the bio‐based flavanone (‐)‐isolonchocarpin from Tephrosia vogelii. Through McMurry homocoupling and light‐driven 6‐π‐electrocyclization, an overcrowded alkene and a fluorescent O‐heterocyclic phenanthrene are synthesized.
Deryl H. Limawan, Adrien Combe, Anthony Bongso, Bayu Dwiputra, Atthar L. Ivansyah, Roza R. Weber, Charlotte N. Stindt, Robby Roswanda, Ben L. Feringa   +8 more
wiley   +1 more source

Towards a Modernized Framework of Histology Teaching to Integrate Genetics: Pedagogical Perspectives for Oral Histology. [PDF]

Genes (Basel)
Kristoffersen CSM, Ziesler CEØ, Thune NH, Kristensen AT, Sehic A, Utheim TP, Khan Q.   +6 more
europepmc   +1 more source