Results 61 to 70 of about 3,164 (230)
Autonomous High‐Throughput Characterization of Liquid‐Liquid Phase Behavior
Advanced Science, EarlyView.This study introduces an automated dual modality platform, combining asymmetric capacitance deviation and multiangle turbidimetry, for high‐throughput characterization of liquid‐liquid phase behavior across chemically diverse fluid systems. The platform enables miscibility classification, resolution of phase separation kinetics and emulsion stability ...
Tarek Eid +3 more
wiley +1 more source
Advanced Science, EarlyView.Combining template stripping with a graphene‐inspired transfer yields continuous, transferable gold films at 6‐inch wafer scale with thicknesses approaching the atomic limit. The atomically smooth, near‐bulk‐quality films offer above 86% transmittance and sub‐20 Ω/square sheet resistance, serving as a universal platform for flexible optoelectronics ...
Dmitry Yakubovsky +24 more
wiley +1 more source
Advanced Science, EarlyView.A concise supramolecular assembly strategy using α‐cyclodextrin and phenylpyridine derivatives affords dual‐functional materials with switchable multicolor photochromism and tunable ultralong organic phosphorescence, offering new platforms for various photonic applications. ABSTRACT Supramolecular photochromic materials capable of reversible alteration
Xue Bai +8 more
wiley +1 more source
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies
Advanced Science, EarlyView.Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi +5 more
wiley +1 more source
Hyperpolarization of Pyridine 15N‐Oxide Molecular Probes Enabled by Parahydrogen
Angewandte Chemie, EarlyView.Pyridine 15N‐oxides are introduced as motifs for hyperpolarization studies and biochemical applications are demonstrated. ABSTRACT Magnetic resonance (MR) is a powerful non‐invasive technique for probing structural, functional, and metabolic processes with high spatial and temporal resolution.
Ruhuai Mei +8 more
wiley +2 more sources
Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy
Advanced Science, EarlyView.This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang +5 more
wiley +1 more source
Angewandte Chemie, EarlyView.Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey +13 more
wiley +2 more sources
Light‐Controlled Conductive Molecular Wire in an Artificial Lipid Membrane
Advanced Science, EarlyView.A photochromic azobenzene derivative is shown to produce a unique photoelectric response when embedded in artificial lipid membranes. In its trans state, it forms conductive “molecular wires” that enhance membrane conductivity in the dark. Light‐induced cis isomerization suppresses this effect, showing that short‐chain molecules can modulate membrane ...
Ilaria Cardace +11 more
wiley +1 more source