Results 71 to 80 of about 3,258 (217)

On‐Surface Friedel–Crafts Alkylation Through a Stabilized Intermediate Complex

open access: yesAngewandte Chemie International Edition, EarlyView.
On‐surface Friedel–Crafts alkylation is demonstrated on Ag(111) at the single‐molecule level. STM, XPS, and DFT calculations uncover the reaction mechanism and explain the stabilization of the key intermediate, providing insight into noble‐metal‐surface‐mediated Csp3${\rm C}_{sp^{3}}$─Csp2${\rm C}_{sp^{2}}$ coupling. ABSTRACT The incorporation of sp3${\
Paul Schweer   +5 more
wiley   +1 more source

The tRNA‐Modification Geranyl‐2‐Thiouridine Enables RNA‐Lipid Association

open access: yesAngewandte Chemie International Edition, EarlyView.
We report the preparation of mono‐ to tri‐geranylated RNA and the association of the hydrophobic RNA with membranes for future efficient incorporation of RNA into liposomes. ABSTRACT The packaging of RNA in lipid nanoparticles for protection and delivery was key for the development of mRNA vaccines and therapeutics. Formulation requires the addition of
Johannes Singer   +3 more
wiley   +1 more source

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