Results 41 to 50 of about 97,714 (259)

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Optimizing FDTD Memory Bandwidth by Using Block Float-Point Arithmetic

Elektronika ir Elektrotechnika, 2018
Finite-difference time-domain is a numerical method used for modelling of computational electrodynamics. The method is resource intensive, especially regarding memory usage. Multiple memory accesses are required per single computation so memory bandwidth
Stefan Pijetlovic, Milos Subotic, Nebojsa Pjevalica   +2 more
doaj   +1 more source

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source

A Hybrid Method for Optimization Modulo Theory of Floating-Point Numbers

Mathematics
Optimization Modulo Theory (OMT) is an important extension of Satisfiability Modulo Theory (SMT), aiming to find models that satisfy constraints while optimizing objective functions. OMT naturally arises in program analysis and formal methods, making OMT
Xu Yang, Liantao Song, Jiaqiang Yao, Zhipan Li, Fan Yu   +4 more
doaj   +1 more source

Numerical Difficulties in Pre-University Informatics Education and Competitions

Informatics in Education, 2003
It is easy to underestimate the difficulties of using floating-point numbers in programming. This is especially the case in pre-university informatics education and competitions, where one is often led to believe that floating-point arithmetic is a good ...
Gyula HORVÁTH, Tom VERHOEFF
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Deep Sequencing of FLT3‐ITD Enables Response Evaluation and Post‐Treatment Monitoring in Childhood AML: An Exploratory Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An internal tandem duplication in the gene encoding Fms‐like tyrosine kinase 3 (FLT3‐ITD) is associated with high relapse risk and poor prognosis in acute myeloid leukemia (AML) and plays a crucial role in treatment decisions. Measurable residual disease (MRD) analysis of FLT3‐ITD during and after treatment has shown prognostic ...
Sofie Johansson Alm, Bea Tornberg, Erik Delsing Malmberg, Henrik Hasle, Kristian Løvvik Juul‐Dam, Lars Palmqvist, Borhan R. Saeed, Giti Shah Barkhordar, Anastasia Soboli, Anna Staffas, Jonas Abrahamsson, Linda Fogelstrand   +11 more
wiley   +1 more source

Design and Implementation of Floating-Point Addition and Floating-Point Multiplication

International Journal for Research in Applied Science and Engineering Technology, 2022
Abstract: In this paper, we present the design and implementation of Floating point addition and Floating point Multiplication. There are many multipliers in existence in which Floating point Multiplication and Floating point addition offers a high precision and more accuracy for the data representation of the image.
openaire   +1 more source

High-Performance Multi-Precision Tool for Floating-Point Computations [PDF]

Radioengineering
This paper presents a MATLAB toolbox for multiple-precision arithmetic, enabling high-precision numerical computations beyond the standard double-precision format. The development step and functionality of the toolbox are described, and how it integrates
L. Leitold, M. Alrwashdeh, Z. Kollar
doaj