Results 161 to 170 of about 52,976 (305)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

The Seroprevalence of Chlamydia abortus in Montana Domestic Rangeland Sheep Varies by Breed, Flock and Herding Practices. [PDF]

Vet Med Sci
Simmons AJ, Borgogna JC, Roeder BL, Yeoman CJ, Posbergh CJ.   +4 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Flock of sheep [6]

, 1951
Photo showing a flock of ...

core  

Fatal Human Case of Highly Pathogenic Avian Influenza A(H5N5) in a Backyard Flock Owner - Washington, November 2025. [PDF]

MMWR Morb Mortal Wkly Rep
Kibiger L, Oltean HN, Leitz L, Krause E, Barrett D, Halloran A, Yomogida K, Lipton B, Paris K, Keirn J, Buswell M, Black A, Trinh P, Murray T, Bonaccorso R, Banuelos L, Dieringer E, Lenahan J, Davizon ES, Marder EP, Mullins J, Kay M, Chow EJ, Valenciano SJ, Lynch J, Makarewicz V, Bryson-Cahn C, Hernandez J, Haggith K, Linn V, Greninger AL, Goya S, Gulla S, Young J, Kerns-Funk S, da Silva Bhatia B, Bruce H, Kniss K, Reinhart K, Ohlstein R, Johnson S, Schofield C, Smith P, Itle A, Gibson M, Torrevillas B, Falghoush A, Waltzek TB, Snekvik K, Torchetti M, Uyeki TM, Lindquist S.   +51 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Snow geese flock

, 2012
Audio of a flock of snow ...

core  

Epidemiological Insights into Small Ruminant Lentiviruses in Portuguese Production Systems. [PDF]

Animals (Basel)
Jacob-Ferreira J, Coelho AC, Vila AG, Lacasta D, Valentim R, Quintas H.   +5 more
europepmc   +1 more source

Flocking in [PDF]

Current Biology, 2009
openaire   +1 more source