Results 61 to 70 of about 882,248 (296)

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

“Unless you are converted and become as little children, you will by no means enter the kingdom of heaven”: the place and role of “children” in the spiritual and moral reform of Savonarola

Гуманитарные и юридические исследования
Introduction. The Dominican preacher Girolamo Savonarola’s theme of attracting children to carry out spiritual and moral transformations in Florence at the end of the 15th century is extremely attractive to researchers.
E. P. Telmenko
doaj   +1 more source

Public Theology in the face of pain and suffering: A proletarian perspective [PDF]

, 2015
A basic understanding of theology is the quest for knowledge of the Divine—the study of God. But why, one may ask, undertake such an endeavour, and to what end? My simple response would be, to know God is to enhance and enrich my life and service.
Juma, Florence
core   +2 more sources

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

DC‐magnetometry Analytical Tool Driven by Spin Ordering Phenomena for Sensing Chemical Interactions at the Surface of Nanomaterials

Advanced Science, EarlyView.
The adsorption of AsV on akaganeite nanorods was found to provide a magnetic signature. A change in the surface spin order gave rise to a second peak in the zero‐field cooled curve. AsIII adsorption does not provide any change in the magnetic behavior of the sorbent.
Marco Sanna Angotzi, Valentina Mameli, Alessandra Fantasia, Cesare Atzori, Giovanni Bertoni, Vincenzo Grillo, Giorgio Divitini, Dominika Zakutna, Jana Vejpravova, Martin Kalbac, Jan Plšek, Carla Cannas   +11 more
wiley   +1 more source

Una fabbrica fiorentina nella Roma del Primo Seicento: la cappella Strozzi in Sant’Andrea della Valle [PDF]

Papireto
The article examines the Strozzi Chapel in Sant’Andrea della Valle, Rome, attributing for the first time its design to Giovanni Battista Caccini (1556–1613) and Lodovico Cardi, known as Cigoli (1559–1613).
Costantino Ceccanti, Carlo Alberto Garzonio   +1 more
doaj   +1 more source

Quantifying Magnetic Anisotropy of Ferroelectric Fe(II) Square‐Pyramidal Systems Using Torque Magnetometry

Advanced Science, EarlyView.
Five‐coordinate, square‐pyramidal Fe(II) complexes adopting polar, non‐centrosymmetric crystal structures exhibit exceptionally large easy‐axis magnetic anisotropy. Ligand‐driven distortions critically control the anisotropy, and the dielectric, Polarization vs Elecric field and piezo response studies confirm intrinsic polarization, positioning these ...
Vijaya Thangaraj, Gemma K. Gransbury, Deepanshu Chauhan, Dipanti Borah, Gopalan Rajaraman, Mauro Perfetti, Maheswaran Shanmugam   +6 more
wiley   +1 more source

Recent Trends in Metabolomics by NMR Spectroscopy

Angewandte Chemie, EarlyView.
AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco, Gaia Meoni, Veronica Ghini, Alessia Vignoli, Leonardo Tenori, Paola Turano, Claudio Luchinat   +6 more
wiley   +2 more sources

High‐Yield Fabrication of Electrolyte‐Gated Transistors Based on Graphene Acetic Acid

Advanced Electronic Materials, EarlyView.
We fabricated a liquid‐gated transistor based on graphene acetic acid, which is dielectrophoretically deposited, featuring a spatial resolution down to 10 microns. Our method enables a versatile and reproducible fabrication featuring state‐of‐the‐art performance.
Georgian Giani Ilie, Lara Franchin, Ludovica Pradetto Battel, Stefano Bonaldo, Alessandro Paccagnella, Biagio di Vizio, Stefano Agnoli, Rafael C. Hensel, Antonio Gaetano Ricciardulli, Simone Battiston, Mauro Sambi, Francesco Sedona, Paolo Samorì, Stefano Casalini   +13 more
wiley   +1 more source

Veliky Novgorod and Florence: a typological comparison of festive culture during the formation of independent republics

Russian Studies in Culture and Society
Background. The article examines the history of cities that won the right to independent republican rule and the development of a popular city holiday as a manifestation of the civic spirit of medieval society.
Tatyana V. Azarova
doaj   +1 more source