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Development of an enzyme-linked immunosorbent assay for the determination of florfenicol and florfenicol amine in eggs [PDF]

Food and Agricultural Immunology, 2020
A monoclonal antibody against florfenicol amine (FFA) was produced, and a competitive enzyme-linked immunosorbent assay (ELISA) was developed for detecting florfenicol (FF) and FFA in eggs. This proposed method exhibited the 50% inhibiting concentrations (IC50) of 0.120 ng/mL for FF and 0.118 ng/mL for FFA under the optimization of experimental ...
Zifei Wang, Pengjie Luo
exaly   +3 more sources

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Pharmacokinetics of florfenicol and its major metabolite, florfenicol amine, in rabbits

Journal of Veterinary Pharmacology and Therapeutics, 2007
The pharmacokinetics of florfenicol and its active metabolite florfenicol amine were investigated in rabbits after a single intravenous (i.v.) and oral (p.o.) administration of florfenicol at 20 mg/kg bodyweight. The plasma concentrations of florfenicol and florfenicol amine were determined simultaneously by an LC/MS method. After i.v.
B-K, Park, J-H, Lim, M-S, Kim, Y-H, Hwang, H-I, Yun   +4 more
openaire   +2 more sources

Pharmacokinetics of florfenicol and florfenicol‐amine after intravenous administration in sheep

Journal of Veterinary Pharmacology and Therapeutics, 2011
Florfenicol (FFC) is a broad spectrum antibacterial agent that is structurally related to chloramphenicol but differs from it by the presence of a para-methyl sulphonyl group instead of the p-nitro group and the presence of a fluorine atom instead of the hydroxyl group in the terminal primary alcohol function (EMEA, 2002).
C, Palma, J, Ramírez, A, Benavente, V, Cazanga, M, Venegas, R, Pérez   +5 more
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Pharmacokinetics and tolerance of florfenicol in Equidae

Equine Veterinary Journal, 1996
Summary Florfenicol was administered to horses and ponies at a dose rate of 22 mg/kg bwt by i.v., i.m. and oral routes. Following i.v. administration it had an elimination half‐life of 1.8 ± 0.9 h, a body clearance of 0.4 ± 0.11/h.kg and a volume of distribution at steady‐state of 0.7 ± 0.2 1/kg. It was highly bioavailable following i.
Q A, McKellar, K J, Varma
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Pharmacokinetics of Florfenicol and Its Metabolite Florfenicol Amine in Atlantic Salmon

Journal of Aquatic Animal Health, 1996
Abstract The plasma pharmacokinetic profile of the antibacterial agent florfenicol was studied in Atlantic salmon Salmo salar in seawater. In a single-dose study, each fish was given 10 mg/kg body weight by intravenous (iv) injection or by oral gavage of feed coated with the drug.
Tor Einar Horsberg, Kjell Arne Hoff, Rolf Nordmo   +2 more
openaire   +1 more source

Pharmacokinetics of florfenicol and thiamphenicol in ducks

Journal of Veterinary Pharmacology and Therapeutics, 2018
AbstractThe pharmacokinetics of florfenicol (FF) and thiamphenicol (TP) after single intravenous (IV) and oral (PO) administration was investigated in Mulard ducks. Both antibiotics were administered at a dose of 30 mg/kg body weight, and their concentrations in plasma samples were assayed using high‐performance liquid chromatography with ultraviolet ...
Marta Tikhomirov, Błażej Poźniak, Andrzej Smutkiewicz, Marcin Świtała   +3 more
openaire   +3 more sources

Pharmacokinetics of florfenicol in veal calves

Journal of Veterinary Pharmacology and Therapeutics, 1986
Varma, K.J., Adams, P.E., Powers, T.E., Powers, J.D. & Lamendola, J.F. Pharmacokinetics of florfenicol in veal calves. J. vet. Pharmacol. Therap. 9, 412–425.The pharmacokinetic disposition of florfenicol was described in veal calves after administration of a single 22‐mg/kg dose intravenously, orally after a 12‐h fast and orally 5 min post feeding.
K J, Varma, P E, Adams, T E, Powers, J D, Powers, J F, Lamendola   +4 more
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Approaches for the simultaneous detection of thiamphenicol, florfenicol and florfenicol amine using immunochemical techniques

Journal of Immunological Methods, 2013
Thiamphenicol and florfenicol are antibacterial agents permitted for use as veterinary drugs in animals used for food production. However, as the EU has established maximum residue limits for both and the metabolite florfenicol amine, there is a requirement to monitor animal food products for their residues.
Fodey, Terence L., George, Suja E., Traynor, Imelda M., Delahaut, Philippe, Glenn Kennedy, D., Elliott, Christopher T., Crooks, Steven R.H.   +6 more
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Determination of extractable and non-extractable florfenicol residues as florfenicol amine in eggs by UPLC-MS/MS

Food Additives & Contaminants: Part A, 2022
Some florfenicol (FF) metabolites have a strong binding affinity towards biomolecules in the edible tissues of some food animals. These bound FF residues cannot be extracted directly from edible tissues with organic solvents and are present in higher concentrations even than solvent extractable residues.
Xia, Li, Yu, Zhang, Qifan, Sun, Min, Ding, Zengmei, Li, Hui, Yue, Ligang, Deng, Lu, Chen   +7 more
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An Enzymatic Route to Florfenicol

Synthesis, 1991
Racemic ethyl threo-3-(4-methylthiophenyl)serinate is resolved by enzymatic hydrolysis using protease from Streptomyces griseus and both stereoisomers are converted to D-threo-4,5-dihydro-5-(4-methylsulfonylphenyl)-2-phenyl-4-oxazolemethanol, thereby giving a formal synthesis of ...
Jon E. Clark, Peter A. Fischer, Doris P. Schumacher   +2 more
openaire   +1 more source