Results 141 to 150 of about 6,330 (184)

An Enzymatic Route to Florfenicol

Synthesis, 1991
Racemic ethyl threo-3-(4-methylthiophenyl)serinate is resolved by enzymatic hydrolysis using protease from Streptomyces griseus and both stereoisomers are converted to D-threo-4,5-dihydro-5-(4-methylsulfonylphenyl)-2-phenyl-4-oxazolemethanol, thereby giving a formal synthesis of ...
Jon E. Clark, Peter A. Fischer, Doris P. Schumacher   +2 more
openaire   +1 more source

An efficient synthesis of florfenicol

The Journal of Organic Chemistry, 1990
An efficient synthesis of florfenicol from commercially available starting materials has been achieved, using low cost and safe reagents.
Doris P. Schumacher, Jon E. Clark, Bruce L. Murphy, Peter A. Fischer   +3 more
openaire   +1 more source

UPLC–MS/MS determination of florfenicol and florfenicol amine antimicrobial residues in tilapia muscle

Journal of Chromatography B, 2016
Despite the benefits to fish farmers, the use of antimicrobials in aquaculture has concerned consumers and competent authorities. The indiscriminate use of such substances promotes the emergence of resistant microorganisms, decreases the effectiveness of treatments, and causes possible toxic effects in humans.
Eduardo Adilson, Orlando, Aline Gabriela, Costa Roque, Marcos Eliseu, Losekann, Ana Valéria, Colnaghi Simionato   +3 more
openaire   +2 more sources

Bioavailability and pharmacokinetics of florfenicol in healthy sheep*

Journal of Veterinary Pharmacology and Therapeutics, 2004
A study on bioavailability and pharmacokinetics of florfenicol was conducted in 20 crossbred healthy sheep following a single intravenous (i.v.) and intramuscular (i.m.) doses of 20 and 30 mg/kg body weight (b.w.). Florfenicol concentrations in serum were determined by a validated high‐performance liquid chromatography method with UV detection at a ...
Jianzhong, Shen, Xiubo, Li, Haiyang, Jiang, Walter H, Hsu, S, Jianzhong, L, Xiubo, J, Haiyang, H H, Walter   +7 more
openaire   +2 more sources

Pharmacokinetics of florfenicol, thiamphenicol, and chloramphenicol in turkeys

Journal of Veterinary Pharmacology and Therapeutics, 2007
The pharmacokinetics of florfenicol (FF), thiamphenicol (TP) and chloramphenicol (CP) after single intravenous (i.v.) or oral (p.o.) administration was studied in an independent cross‐over study in broiler turkeys. All the fenicol antibiotics were administered at a dose of 30 mg/kg b.w.
Marcin Świtała, Hrynyk, R., A. Smutkiewicz, Krzysztof Jaworski, Paweł Pawłowski, P. Okoniewski, Tomasz Grabowski, Debowy, J.   +7 more
openaire   +2 more sources

Depletion of florfenicol and florfenicol amine in eggs of laying hens and growing pullets after oral administration

Food Additives & Contaminants: Part A, 2020
In this study, we carried out two experiments to evaluate depletion of florfenicol (FF) and its metabolite florfenicol amine (FFA) in eggs from growing pullets and laying hens. Eggs were collected, and the egg white and yolk were separated. FF and FFA were analysed by liquid chromatography-tandem mass spectrometry.
Xia, Li, Lu, Chen, Hui, Yue, Hua, Feng, Enmin, Xu, Xiuli, Wei, Xiaoli, Han, Ligang, Deng, Zengmei, Li   +8 more
openaire   +2 more sources

Pharmacokinetics of florfenicol in the plasma of Japanese quail

New Zealand Veterinary Journal, 2009
To determine the pharmacokinetics and bioavailability of florfenicol in the plasma of healthy Japanese quail (Coturnix japonica).Sixty-five quail were given an I/V and I/M dose of florfenicol at 30 mg/kg bodyweight (BW). A two-period sequential design was used, with a wash-out period of 2 weeks between the different routes of administration ...
KOC, Feride, KADIOĞLU, Yücel, ATİLA, Alptuğ, ÖZTÜRK, Meryem, Uney, K.   +4 more
openaire   +4 more sources

Use of florfenicol in non‐human primates

Journal of Medical Primatology, 2004
Abstract:  Studies were undertaken to determine if florfenicol, an antimicrobial agent structurally similar to chloramphenicol, could be used as an effective broad spectrum antibiotic for the treatment of bacterial infections in primates. Florfenicol was developed as an injectable antibiotic for use in cattle on an every other day dosing schedule.
Anthony L, Cook, Marisa, St Claire, Richard, Sams   +2 more
openaire   +2 more sources

Residue Depletion of Florfenicol and Its Metabolite Florfenicol Amine in Swine Tissues after Intramuscular Administration

Journal of Agricultural and Food Chemistry, 2006
A study of the tissue depletion of florfenicol (FF) administered intramuscularly twice to swine at a dose rate of 20 mg per kg of body weight at 24 h intervals was carried out. Forty healthy cross swine were treated with the FF injection formulation.
Jiancheng, Li, Shuangyang, Ding, Suxia, Zhang, Cun, Li, Xiaowei, Li, Zhongwei, Liu, Jinfeng, Liu, Jianzhong, Shen   +7 more
openaire   +2 more sources

Intravenous and subcutaneous pharmacokinetics of florfenicol in sheep

Journal of Veterinary Pharmacology and Therapeutics, 2004
Pharmacokinetic parameters of florfenicol were determined in 10 adult sheep (five wethers and five ewes) after a single 40 mg/kg intravenous (i.v.) dose, and three daily subcutaneous (s.c.) doses of 40 mg/kg of a commercial preparation (Nuflor®). The concentration of florfenicol in serum samples was assayed using a proprietary HPLC assay method, and ...
V M, Lane, A, Villarroel, S E, Wetzlich, S, Wetzlich, A, Clifford, I, Taylor, A L, Craigmill   +6 more
openaire   +2 more sources