Results 141 to 150 of about 6,579 (185)

An efficient synthesis of florfenicol

The Journal of Organic Chemistry, 1990
An efficient synthesis of florfenicol from commercially available starting materials has been achieved, using low cost and safe reagents.
Doris P. Schumacher, Jon E. Clark, Bruce L. Murphy, Peter A. Fischer   +3 more
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Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus)

Journal of Veterinary Pharmacology and Therapeutics, 2006
The pharmacokinetics of florfenicol and its metabolite, florfenicol amine, was investigated after its intravenous (i.v.) and oral (p.o.) administration of 20 mg/kg of body weight in Korean catfish (Silurus asotus). After i.v. florfenicol injection (as a bolus), the terminal half‐life (t1/2), the volume of distribution at steady state (Vdss), and total ...
B-K, Park, J-H, Lim, M-S, Kim, H-I, Yun
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UPLC–MS/MS determination of florfenicol and florfenicol amine antimicrobial residues in tilapia muscle

Journal of Chromatography B, 2016
Despite the benefits to fish farmers, the use of antimicrobials in aquaculture has concerned consumers and competent authorities. The indiscriminate use of such substances promotes the emergence of resistant microorganisms, decreases the effectiveness of treatments, and causes possible toxic effects in humans.
Eduardo Adilson, Orlando, Aline Gabriela, Costa Roque, Marcos Eliseu, Losekann, Ana Valéria, Colnaghi Simionato   +3 more
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Pharmacokinetics of florfenicol, thiamphenicol, and chloramphenicol in turkeys

Journal of Veterinary Pharmacology and Therapeutics, 2007
The pharmacokinetics of florfenicol (FF), thiamphenicol (TP) and chloramphenicol (CP) after single intravenous (i.v.) or oral (p.o.) administration was studied in an independent cross‐over study in broiler turkeys. All the fenicol antibiotics were administered at a dose of 30 mg/kg b.w.
Marcin Świtała, Hrynyk, R., A. Smutkiewicz, Krzysztof Jaworski, Paweł Pawłowski, P. Okoniewski, Tomasz Grabowski, Debowy, J.   +7 more
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Bioavailability and pharmacokinetics of florfenicol in healthy sheep*

Journal of Veterinary Pharmacology and Therapeutics, 2004
A study on bioavailability and pharmacokinetics of florfenicol was conducted in 20 crossbred healthy sheep following a single intravenous (i.v.) and intramuscular (i.m.) doses of 20 and 30 mg/kg body weight (b.w.). Florfenicol concentrations in serum were determined by a validated high‐performance liquid chromatography method with UV detection at a ...
Jianzhong, Shen, Xiubo, Li, Haiyang, Jiang, Walter H, Hsu, S, Jianzhong, L, Xiubo, J, Haiyang, H H, Walter   +7 more
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Depletion of florfenicol and florfenicol amine in eggs of laying hens and growing pullets after oral administration

Food Additives & Contaminants: Part A, 2020
In this study, we carried out two experiments to evaluate depletion of florfenicol (FF) and its metabolite florfenicol amine (FFA) in eggs from growing pullets and laying hens. Eggs were collected, and the egg white and yolk were separated. FF and FFA were analysed by liquid chromatography-tandem mass spectrometry.
Xia, Li, Lu, Chen, Hui, Yue, Hua, Feng, Enmin, Xu, Xiuli, Wei, Xiaoli, Han, Ligang, Deng, Zengmei, Li   +8 more
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Pharmacokinetics of florfenicol in the plasma of Japanese quail

New Zealand Veterinary Journal, 2009
To determine the pharmacokinetics and bioavailability of florfenicol in the plasma of healthy Japanese quail (Coturnix japonica).Sixty-five quail were given an I/V and I/M dose of florfenicol at 30 mg/kg bodyweight (BW). A two-period sequential design was used, with a wash-out period of 2 weeks between the different routes of administration ...
KOC, Feride, KADIOĞLU, Yücel, ATİLA, Alptuğ, ÖZTÜRK, Meryem, Uney, K.   +4 more
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Use of florfenicol in non‐human primates

Journal of Medical Primatology, 2004
Abstract:  Studies were undertaken to determine if florfenicol, an antimicrobial agent structurally similar to chloramphenicol, could be used as an effective broad spectrum antibiotic for the treatment of bacterial infections in primates. Florfenicol was developed as an injectable antibiotic for use in cattle on an every other day dosing schedule.
Anthony L, Cook, Marisa, St Claire, Richard, Sams   +2 more
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Intravenous and subcutaneous pharmacokinetics of florfenicol in sheep

Journal of Veterinary Pharmacology and Therapeutics, 2004
Pharmacokinetic parameters of florfenicol were determined in 10 adult sheep (five wethers and five ewes) after a single 40 mg/kg intravenous (i.v.) dose, and three daily subcutaneous (s.c.) doses of 40 mg/kg of a commercial preparation (Nuflor®). The concentration of florfenicol in serum samples was assayed using a proprietary HPLC assay method, and ...
V M, Lane, A, Villarroel, S E, Wetzlich, S, Wetzlich, A, Clifford, I, Taylor, A L, Craigmill   +6 more
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Bioavailability and pharmacokinetics of florfenicol in broiler chickens

Journal of Veterinary Pharmacology and Therapeutics, 2003
The bioavailability and pharmacokinetic disposition of florfenicol in broiler chickens were investigated after intravenous (i.v.), intramuscular (i.m.) and oral administrations of 15 and 30 mg/kg body weight (b.w.). Plasma concentrations of florfenicol were determined by a high performance liquid chromatographic method in which plasma samples were ...
J, Shen, D, Hu, X, Wu, J R, Coats
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