Similar Gastro-Intestinal Exposure to Florfenicol After Oral or Intramuscular Administration in Pigs, Leading to Resistance Selection in Commensal Escherichia coli [PDF]
Frontiers in Pharmacology, 2018 Florfenicol, which is licensed for veterinary use only, proves to be a potent antimicrobial for treatment of respiratory disease. However, the subsequent exposure of the gut microbiota to florfenicol is not well described.
Joren De Smet +6 more
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Impacts of florfenicol on the microbiota landscape and resistome as revealed by metagenomic analysis [PDF]
Microbiome, 2019 Background Drug-resistant fish pathogens can cause significant economic loss to fish farmers. Since 2012, florfenicol has become an approved drug for treating both septicemia and columnaris diseases in freshwater fish.
Qifan Zeng +3 more
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Veterinary Medicine International, 2023 Florfenicol is a broad-spectrum antibiotic belonging to the amphenicols class that inhibits protein synthesis by binding to bacteria's ribosomal subunits. This drug is commonly used in veterinary medicine to treat bacterial infectious diseases in cattle,
Anisa Bardhi +4 more
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Intracellular Accumulation of Linezolid and Florfenicol in OptrA-Producing Enterococcus faecalis and Staphylococcus aureus [PDF]
Molecules, 2018 The optrA gene, which confers transferable resistance to oxazolidinones and phenicols, is defined as an ATP-binding cassette (ABC) transporter but lacks transmembrane domains. The resistance mechanism of optrA and whether it involves antibiotic efflux or
Yingyu Wang +5 more
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Florfenicol Resistance in Enterobacteriaceae and Whole-Genome Sequence Analysis of Florfenicol-Resistant Leclercia adecarboxylata Strain R25 [PDF]
International Journal of Genomics, 2019 Due to inappropriate use, florfenicol resistance is becoming increasingly serious among animal respiratory tract and gut bacteria. To detect the florfenicol resistance mechanism among Enterobacteriaceae bacteria, 292 isolates from animal feces were ...
Yuanyuan Ying +12 more
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Subinhibitory concentrations of florfenicol enhance the adherence of florfenicol-susceptible and florfenicol-resistant Staphylococcus aureus [PDF]
Journal of Antimicrobial Chemotherapy, 2004 (Applied Biosystems, Foster City, CA, USA). This allowed detection of mutations at nucleotide position 913, and also confirmed PCR-RFLP results. PCR-RFLP analysis discriminated the blaTEM genes into three restriction linkage groups (according to polymorphic sequence variations) (Table 1): the ‘TEM-1A type’ (n = 1), the ‘TEM-1B type’ (n = 14) and the ...
Maren, Blickwede +2 more
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Frontiers in Microbiology, 2021 Pasteurella multocida can invade and translocate through endothelial cells and result in vascular-system infection, which can cause severe economic losses in the poultry industry.
Xia Xiao +15 more
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Natural and experimental salinomycin poisoning associated with the use of florfenicol in pigs [PDF]
Pesquisa Veterinária Brasileira, 2022 : This study describes the spontaneous and experimental salinomycin poisoning associated with the use of florfenicol and warns about the effects of the administration of antibiotics to animals that receive ionophores in the feed as growth promoters.
Amanda Q. Carvalho +5 more
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Florfenicol - pharmacodynamic, pharmacokinetics and clinical efficacy of oral formulations in domestic animals: A systematic review [PDF]
Veterinarski Glasnik, 2005 Porcine respiratory disease complex (PRDC) is a major economic problem for swine producers world-wide. Pharmacodynamic, pharmacokinetics and clinical efficacy of florfenicol oral formulations in domestic animals were evaluated.
Ščuka Leon
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Antibiotics, 2023 Florfenicol is one of the most widely used antibiotics in aquaculture and veterinary clinics because of its low side effects and strong bactericidal effect.
Tengyue Zhang +7 more
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