Results 21 to 30 of about 26,429 (256)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Childhood antecedents of adult place satisfaction in 22 countries

Scientific Reports
We examine how childhood predictors—including retrospectively reported familial relationships, socioeconomic status, health, and religious activities—potentially influence satisfaction with the area or city where one lives (i.e., place satisfaction) in ...
Victor Counted, Dorota Weziak-Bialowolska, Richard G. Cowden, Byron R. Johnson, Tyler J. VanderWeele   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Longitudinal associations of dispositional forgivingness with multidimensional well-being: a two-wave outcome-wide analysis in the Global Flourishing Study

npj Mental Health Research
In this preregistered longitudinal study with nationally representative samples from 23 countries in the Global Flourishing Study (N = 207,919), we examine associations between dispositional forgivingness and multidimensional well-being outcomes ...
Richard G. Cowden, Everett L. Worthington, R. Noah Padgett, Chris Felton, Dorota Weziak-Bialowolska, Renae Wilkinson, Katherine Jackson-Meyer, Zhuo J. Chen, Matt Bradshaw, Byron R. Johnson, Tyler J. VanderWeele   +10 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Early life experiences and adult orientation to promote good in 22 countries

Scientific Reports
Prior research suggests associations between character involving an orientation to promote good (i.e., a disposition to take actions that contribute to the good of oneself and others) and improved well-being outcomes.
Ying Chen, Eric S. Kim, Julia S. Nakamura, Dorota Weziak-Bialowolska, Renae Wilkinson, R. Noah Padgett, Byron R. Johnson, Tyler J. VanderWeele   +7 more
doaj   +1 more source

Bridging across differences toward flourishing in the profession of medicine

Social Sciences and Humanities Open
Bridging is a facilitative process that advances human flourishing by providing a framework for engagement across groups and between individuals with different views. It aims to increase understanding and find common ground.
Cheryl Maurana, Heather Carroll, Alicia Witten, Sarah Williams, Kimara Ellefson, Sue Cox, Marissa Kalkman, Alverno Devine, Christine Cassel   +8 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Identifying childhood correlates of adult purpose and meaning across 22 countries (Global Flourishing Study)

npj Mental Health Research
How might we cultivate a life imbued with purpose and meaning? Though common experience indicates purpose and meaning are inherently important, empirical evidence confirms they are also linked to improved health/well-being. However, childhood antecedents
Eric S. Kim, Matt Bradshaw, R. Noah Padgett, Ying Chen, Koichiro Shiba, James L. Ritchie-Dunham, Brendan W. Case, Byron R. Johnson, Tyler J. VanderWeele   +8 more
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source