Results 21 to 30 of about 26,306 (256)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Childhood antecedents of adult place satisfaction in 22 countries

Scientific Reports
We examine how childhood predictors—including retrospectively reported familial relationships, socioeconomic status, health, and religious activities—potentially influence satisfaction with the area or city where one lives (i.e., place satisfaction) in ...
Victor Counted, Dorota Weziak-Bialowolska, Richard G. Cowden, Byron R. Johnson, Tyler J. VanderWeele   +4 more
doaj   +1 more source

Barriers to access to antiretroviral therapy by people living with HIV in an indonesian remote district during the COVID-19 pandemic: a qualitative study

BMC Infectious Diseases, 2023
Background Coronavirus disease (COVID-19) pandemic has a significant influence on the access to healthcare services. This study aimed to understand the views and experiences of people living with HIV (PLHIV) about barriers to their access to ...
Nelsensius Klau Fauk, Hailay Abrha Gesesew, Alfonsa Liquory Seran, Paul Russell Ward   +3 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Longitudinal associations of dispositional forgivingness with multidimensional well-being: a two-wave outcome-wide analysis in the Global Flourishing Study

npj Mental Health Research
In this preregistered longitudinal study with nationally representative samples from 23 countries in the Global Flourishing Study (N = 207,919), we examine associations between dispositional forgivingness and multidimensional well-being outcomes ...
Richard G. Cowden, Everett L. Worthington, R. Noah Padgett, Chris Felton, Dorota Weziak-Bialowolska, Renae Wilkinson, Katherine Jackson-Meyer, Zhuo J. Chen, Matt Bradshaw, Byron R. Johnson, Tyler J. VanderWeele   +10 more
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Variations in character involving an orientation to promote good across sociodemographic groups in 22 countries

Scientific Reports
An orientation to promote good (i.e., a disposition to take actions that contribute to the good of oneself and others) has been associated with better health and well-being outcomes.
Ying Chen, Dorota Weziak-Bialowolska, Eric S. Kim, Julia S. Nakamura, Jeffrey A. Hanson, R. Noah Padgett, Byron R. Johnson, Tyler J. VanderWeele   +7 more
doaj   +1 more source

Bridging across differences toward flourishing in the profession of medicine

Social Sciences and Humanities Open
Bridging is a facilitative process that advances human flourishing by providing a framework for engagement across groups and between individuals with different views. It aims to increase understanding and find common ground.
Cheryl Maurana, Heather Carroll, Alicia Witten, Sarah Williams, Kimara Ellefson, Sue Cox, Marissa Kalkman, Alverno Devine, Christine Cassel   +8 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source