Results 91 to 100 of about 3,286,488 (309)

A Two-Stage Three-Machine Flow Shop Assembly Problem Mixed with a Controllable Number and Sum-of-Processing Times-Based Learning Effect by Simulated Annealing Algorithms

Discrete Dynamics in Nature and Society, 2020
The two-stage assembly scheduling problem is widely used in industrial and service industries. This study focuses on the two-stage three-machine flow shop assembly problem mixed with a controllable number and sum-of-processing times-based learning effect,
Shang-Chia Liu
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Multi-Objective Parallel Variable Neighborhood Search for Energy Consumption Scheduling in Blocking Flow Shops

IEEE Access, 2018
Blocking flow shop scheduling problem has been extensively studied because of its widespread industrial applications. However, the existing research mostly aims at makespan or total flow time minimization and ignores the criterion for energy saving. This
Fucai Wang, Guanlong Deng, Tianhua Jiang, Shuning Zhang   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Better approximation guarantees for job-shop scheduling [PDF]

Job-shop scheduling is a classical NP-hard problem. Shmoys, Stein and Wein presented the first polynomial-time approximation algorithm for this problem that has a good (polylogarithmic) approximation guarantee.
Paterson, Michael S., Srinavasan, Aravind, Goldberg, Leslie Ann, Sweedyk, Elizabeth   +3 more
core  

MODEL PENJADWALAN BACKWARD HYBRID FLOW SHOP 2 STAGE UNTUK MEMINIMASI MEAN FLOWTIME

Jurnal Lebesgue
The scheduling problem is a common challenge when it comes to executing tasks, making the resolution of this issue crucial for decision-making in production activities.
Asep Anwar, Rendiyatna Ferdian, Didit Damur Rochman   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Stochastic flow shop scheduling with random machine breakdowns

, 2003
This paper deals with scheduling problems in m machines permutation flow shop subject to random breakdowns. The processing time of each job on each machine is a random variable.
Zhu YL(朱云龙), Li SF(李素粉)
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source