Results 71 to 80 of about 15,254 (266)

A Two-Stage Three-Machine Flow Shop Assembly Problem Mixed with a Controllable Number and Sum-of-Processing Times-Based Learning Effect by Simulated Annealing Algorithms

open access: yesDiscrete Dynamics in Nature and Society, 2020
The two-stage assembly scheduling problem is widely used in industrial and service industries. This study focuses on the two-stage three-machine flow shop assembly problem mixed with a controllable number and sum-of-processing times-based learning effect,
Shang-Chia Liu
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

MODEL PENJADWALAN BACKWARD HYBRID FLOW SHOP 2 STAGE UNTUK MEMINIMASI MEAN FLOWTIME

open access: yesJurnal Lebesgue
The scheduling problem is a common challenge when it comes to executing tasks, making the resolution of this issue crucial for decision-making in production activities.
Asep Anwar   +2 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Flow shop scheduling with heterogeneous workers

open access: yesEuropean Journal of Operational Research, 2014
We propose an extension to the flow shop scheduling problem named Heterogeneous Flow Shop Scheduling Problem (Het-FSSP), where two simultaneous issues have to be resolved: finding the best worker assignment to the workstations, and solving the corresponding scheduling problem. This problem is motivated by Sheltered Work centers for Disabled, whose main
Alexander J. Benavides   +2 more
openaire   +4 more sources

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Workload Control in Flow Shops with Bottleneck Shifting and Process Time Variability

open access: yesProduction Engineering Archives
Manufacturing industries struggle to devise precise planning and scheduling solutions due to unpredictable business situations. Additionally, uncertainties in production such as machine breakdowns, labour absenteeism, cycle time deviations, etc., would ...
Prabhu Aruna   +2 more
doaj   +1 more source

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