Results 51 to 60 of about 15,254 (266)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

On the Recursive Representation of the Permutation Flow and Job Shop Scheduling Problems and Some Extensions

open access: yesMathematics
In this paper, we propose a formulation of the permutation flow and job shop scheduling problems using special recursive functions and show its equivalence to the existing classical formulation.
Boris Kupriyanov   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

PERBANDINGAN KINERJA ALGORITMA GENETIKA DAN ALGORITMA HEURISTIK RAJENDRAN UNTUK PENJADUALAN PRODUKSI JENIS FLOW SHOP

open access: yesJurnal Teknik Industri, 1999
Flow shop scheduling problem is to schedule a production process of n jobs that go through the same process sequence and the same m machines. Most researches are don to accomplish only one objective, i.e. minimizing makespan. The other objective, such as
Tessa Vanina Soetanto   +2 more
doaj  

Permutation, no-wait, no-idle flow shop problems

open access: yesArchives of Control Sciences, 2015
The paper compares the schedules of different variants of the flow shop problem, i.e. permutation, no waiting and no idle flow shop problems. It is assessed the impact of the constraints on the extension of the schedules and correlations of the length of
Makuchowski Mariusz
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Avaliação de regras de sequenciamento da produção em ambientes Job shop e Flow shop por meio de simulação computacional

open access: yesExacta, 2012
Neste trabalho, a simulação computacional é empregada para estudar os efeitos das regras de sequenciamento de produção no desempenho de ambientes de manufatura job shop e flow shop.
Edna Barbosa da Silva   +3 more
doaj   +1 more source

A Note on Heuristics of Flow-Shop Scheduling [PDF]

open access: yesOperations Research, 1996
We present an O(mn) two-group (TG) heuristic for the m-machine, n-job permutation flow-shop scheduling problem. We show that heuristic TG has a worst-case performance ratio of (m + 1)/2. We also establish worst-case bounds for several heuristics proposed in the past.
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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