Results 51 to 60 of about 9,261 (218)

A Three-Dimensional Model of Turbulent Core Annular Flow Regime

open access: yesJournal of Mathematics, 2021
In this study, three-dimensional (3D) turbulent core annular flow (CAF) regime is investigated numerically. The proposed model is based on the 3D Reynolds average Navier–Stokes (RANS) equations combined with a pure convective transport equation of the ...
Saliha Nouri   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Hydrodynamic Numerical Analysis of Wave Pattern Due to the Motion of Suboff 5470 Underwater Vehicle Near the Free Surface

open access: yesنشریه مهندسی دریا, 2019
The wave pattern generated by motion of autonomous underwater vehicle (AUV) near the water free surface is one of the significant factors in order to identify the AUV. In this research, firstly simulating the flow with constant velocity around the Wigley
masih honarmand   +2 more
doaj  

Infotaxis in a turbulent 3D channel flow

open access: yesJournal of Computational and Applied Mathematics, 2017
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
A. W. Eggels   +3 more
openaire   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Dam-Break Flows: Comparison between Flow-3D, MIKE 3 FM, and Analytical Solutions with Experimental Data

open access: yesApplied Sciences, 2018
The objective of this study was to evaluate the applicability of a flow model with different numbers of spatial dimensions in a hydraulic features solution, with parameters such a free surface profile, water depth variations, and averaged velocity ...
Hui Hu, Jianfeng Zhang, Tao Li
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Statistical analysis of three‐dimensional optical flow separability in volumetric images

open access: yesIET Computer Vision, 2015
Three‐dimensional (3D) motion analysis of dynamic body organs using volumetric images is of increasing interest in different computer vision applications. A number of methods for estimation of 3D optical flow in those images have been developed in recent
Marjan Hadian Jazi   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

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