Results 101 to 110 of about 521,952 (287)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Continuous-flow synthesis and purification of atropine with sequential in-line separations of structurally similar impurities

, 2015
Flow chemistry has attracted significant interest in pharmaceutical development, where substantial efforts have been directed toward the design of continuous processes.
Timothy F. Jamison, Dai, Chunhui, Chunhui Dai, Ping Zhang, Snead, David, Jamison, Timothy F., Zhang, Ping, David R. Snead   +7 more
core   +1 more source

Iron-catalyzed cross-coupling of alkynyl and styrenyl chlorides with alkyl grignard reagents in batch and flow [PDF]

, 2019
\u3cp\u3eTransition-metal-catalyzed cross-coupling chemistry can be regarded as one of the most powerful protocols to construct carbon-carbon bonds. While the field is still dominated by palladium catalysis, there is an increasing interest to develop ...
Wei, Xiao Jing, Yuhan Sun, Deng, Yuchao, Yuchao Deng, Xiao‐Jing Wei, Xiao Wang, Sun, Yuhan, Noël, Timothy, Wei, X, Noël, T Timothy, Wang, Xiao, Timothy Noël   +11 more
core   +1 more source

Inflating hollow nanocrystals through a repeated Kirkendall cavitation process

Nature Communications, 2017
Owing to their unique properties, hollow metal nanocrystals demonstrate greater catalytic promise than their solid counterparts. Here the authors produce hollow and inflated palladium nanocrystals with thin shells via a repeated Kirkendall cavitation ...
He Tianou, Weicong Wang, Xiaolong Yang, Zhenming Cao, Qin Kuang, Zhao Wang, Zhiwei Shan, Mingshang Jin, Yadong Yin   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The role of flow in green chemistry and engineering [PDF]

, 2013
Flow chemistry and continuous processing can offer many ways to make synthesis a more sustainable practice. These technologies help bridge the large gap between academic and industrial settings by often providing a more reproducible, scalable, safe and ...
Newman, Stephen G., Jensen, Klavs F.
core   +1 more source

Gas bubbles have controversial effects on Taylor flow electrochemistry

, 2021
Electrochemistry is currently resurging in popularity amongst synthetic chemists due to the unique opportunities it provides to activate organic molecules. Simultaneously, continuous-flow technology has been used to enable scalability and to increase the
Soares, Cíntia, Padoin, Natan, Cao, Yiran, Noël, Timothy   +3 more
core   +1 more source

Photocatalytic deaminative benzylation and alkylation of tetrahydroisoquinolines with N-alkylpyrydinium salts

Beilstein Journal of Organic Chemistry, 2020
A ruthenium-catalyzed photoredox coupling of substituted N-aryltetrahydroisoquinolines (THIQs) and different bench-stable pyridinium salts was successfully developed to give fast access to 1-benzyl-THIQs.
David Schönbauer, Carlo Sambiagio, Timothy Noël, Michael Schnürch   +3 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A mild and fast photocatalytic trifluoromethylation of thiols in batch and continuous-flow

, 2014
S-CF3 bonds are important structural motifs in various pharmaceutical and agrochemical compounds. However, their preparation remains a major challenge in synthetic organic chemistry.
Tegelbeckers, Bart JP, Hessel, Volker, Straathof, Natan JW, Noël, Timothy, Hessel, V., Noël, T Timothy, Wang, X Xiao-Hua = Xiaohua, Tegelbeckers, B.J.P., Tegelbeckers, BJP Bart, Straathof, N.J.W., Noel, T., Straathof, NJW Natan, Wang, X., Wang, Xiao, Hessel, V   +14 more
core   +1 more source