Results 81 to 90 of about 1,479,587 (285)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
, 2020 Flow chemistry is an expanding area of chemistry. Today, it is also starting to contribute to the development of new and exciting sustainable and green methods to new chemicals and materials. In this special issue, we have collected papers from leading scientists in the field presenting numerous examples illustrating the power of flow chemistry.
Paradisi, Francesca, Woodley, John M.
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Simulation of hydrogen auto-ignition in a turbulent co-flow of heated air with LES and CMC approach [PDF]
, 2011 Large-Eddy Simulations (LES) with the first order Conditional Moment Closure (CMC) approach of a nitrogen-diluted hydrogen jet, igniting in a turbulent co-flowing hot air stream, are discussed. A detailed mechanism (nine species, 19 reactions) is used to
Lacor, Chris +4 more
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
TASK Quarterly, 2018 Numerical modelling of hydrogen production by means of methanol decomposition in a thermocatalytic reactor using corrugated foil made of the Ni3Al intermetallic phase is shown in the paper.
PAWEŁ ZIÓŁKOWSKI +5 more
doaj +1 more source
Point-particle method to compute diffusion-limited cellular uptake [PDF]
, 2017 We present an efficient point-particle approach to simulate reaction-diffusion processes of spherical absorbing particles in the diffusion-limited regime, as simple models of cellular uptake.
Boffetta, G. +4 more
core +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Peptide Bond Formations through Flow Chemistry [PDF]
Chemical Biology & Drug Design, 2017 Flow chemistry could play a key role in the development of fast‐automated synthesis of peptides and proteins through the quick activation of intermediates for coupling at low concentrations of reagents. The selected examples highlight the role of flow chemistry for the advancements of peptides bond formations.
openaire +5 more sources
A study of numerical methods for hyperbolic conservation laws with stiff source terms [PDF]
The proper modeling of nonequilibrium gas dynamics is required in certain regimes of hypersonic flow. For inviscid flow this gives a system of conservation laws coupled with source terms representing the chemistry.
Leveque, R. J., Yee, H. C.
core +1 more source