Results 81 to 90 of about 521,952 (287)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Metal-free photocatalytic cross-electrophile coupling enables C1 homologation and alkylation of carboxylic acids with aldehydes

Nature Communications
In contemporary drug discovery, enhancing the sp3-hybridized character of molecular structures is paramount, necessitating innovative synthetic methods.
Stefano Bonciolini, Antonio Pulcinella, Matteo Leone, Debora Schiroli, Adrián Luguera Ruiz, Andrea Sorato, Maryne A. J. Dubois, Ranganath Gopalakrishnan, Geraldine Masson, Nicola Della Ca’, Stefano Protti, Maurizio Fagnoni, Eli Zysman-Colman, Magnus Johansson, Timothy Noël   +14 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Safety assessment in development and operation of modular continuous-flow processes

, 2017
Improved safety is one of the main drivers for microreactor application in chemical process development and small-scale production. Typical examples of hazardous chemistry are presented indicating potential risks also in miniaturized equipment.
Kockmann, N, Christoph Fleischer-Trebes, Laudadio, G., Noël, T., Fleischer-Trebes, Christoph, Gabriele Laudadio, Thenée, P., Thenée, Philipp, Noël, T Timothy, Timothy Noël, Laudadio, G.; id_orcid, Philipp Thenée, Laudadio, G, Norbert Kockmann, Kockmann, N., Fleischer-Trebes, C.   +15 more
core   +1 more source

The fundamentals behind the use of flow reactors in electrochemistry [PDF]

, 2019
ConspectusIn the past decade, research into continuous-flow chemistry has gained a lot of traction among researchers in both academia and industry.
Yiran Cao, Laudadio, Gabriele; id_orcid, Cao, Yiran, Laudadio, G, Gabriele Laudadio, Laudadio, Gabriele, Cao, Y, Noël, Timothy, Noël, T Timothy, Timothy Noël   +9 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Uniqsis – accessible flow chemistry

Green Processing and Synthesis, 2012
No abstract available.
Pergande Paul
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2‑Heteroarene Migration of Allylic Alcohols in Batch and Flow [PDF]

, 2018
A convenient method for the preparation of sp3-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcohols.
Timothy Noël (1407436), Wei, X., Noël, T., Wei, X, Noël, T Timothy, Xiao-Jing Wei (1716976)   +5 more
core   +1 more source

Dual-Purpose Photometric-Conductivity Detector for Simultaneous and Sequential Measurements in Flow Analysis

Molecules, 2020
This work presents a new dual-purpose detector for photometric and conductivity measurements in flow-based analysis. The photometric detector is a paired emitter–detector diode (PEDD) device, whilst the conductivity detection employs a capacitively ...
Thitirat Mantim, Korbua Chaisiwamongkhol, Kanchana Uraisin, Peter C. Hauser, Prapin Wilairat, Duangjai Nacapricha   +5 more
doaj   +1 more source