Results 61 to 70 of about 521,952 (287)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Accelerating sulfonyl fluoride synthesis through electrochemical oxidative coupling of thiols and potassium fluoride in flow [PDF]
, 2020 Sulfonyl fluorides are valuable synthetic motifs which are currently of high interest due to the popularity of the sulfur (VI) fluoride exchange (SuFEx) click chemistry concept.
Adriaenssens, Benjamin +6 more
core +1 more source
Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles
Molecules, 2020 Indole derivatives are among the most useful and interesting heterocycles employed in drug discovery and medicinal chemistry. In addition, flow chemistry and flow technology are changing the synthetic paradigm in the field of modern synthesis.
Marco Colella +2 more
doaj +1 more source
Four-layer folding framework: design, GAP synthesis, and aggregation-induced emission
Frontiers in Chemistry, 2023 The design and synthesis of a type of [1 + 4 + 2] four-layer framework have been conducted by taking advantage of Suzuki–Miyaura cross-coupling and group-assisted purification (GAP) chemistry.
Sai Zhang +5 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Nature CommunicationsIn recent years, there has been a growing demand for drug design approaches that incorporate a higher number of sp3-hybridized carbons, necessitating the development of innovative cross-coupling strategies to reliably introduce aliphatic fragments. Here,
Ting Wan +6 more
doaj +1 more source
Solvent Resistant O2 Sensor Integrated in Pressured Flow Reactors
Proceedings, 2019 In this contribution we present an optical oxygen sensor that can easily be integrated into continuous flow reactors. The sensors are pressure resistant to up to 8 bars and are able to continuously measure oxygen for several hours in organic solvents ...
Philipp Sulzer, René Lebl, Torsten Mayr
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Making chemistry fit for flow and transforming it to intensified end-to-end process design [PDF]
, 2014 Micro Process Technology has given strong push to continuous chemical manufacture via facilitating heat and mass transfer; named transport intensification The next big step was to develop a tailored process chemistry in flow under highly intensified ...
Wang, Q. +7 more
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