Results 51 to 60 of about 1,479,587 (285)
Nature CommunicationsIn recent years, there has been a growing demand for drug design approaches that incorporate a higher number of sp3-hybridized carbons, necessitating the development of innovative cross-coupling strategies to reliably introduce aliphatic fragments. Here,
Ting Wan +6 more
doaj +1 more source
Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review
Green Synthesis and CatalysisHepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments, substantial gaps remain in the management of chronic ...
Houzong Yao +5 more
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Continuous Flow Synthesis of Heterocycles: A Recent Update on the Flow Synthesis of Indoles
Molecules, 2020 Indole derivatives are among the most useful and interesting heterocycles employed in drug discovery and medicinal chemistry. In addition, flow chemistry and flow technology are changing the synthetic paradigm in the field of modern synthesis.
Marco Colella +2 more
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Layer-by-layer biofabrication of coronary covered stents with clickable elastin-like recombinamers [PDF]
, 2019 Producción CientíficaCoronary artery disease is the leading cause of death around the world. Endovascular stenting is the preferred treatment option to restore blood flow in the coronary arteries due to the lower perioperative morbidity when compared ...
Fernández Colino, Alicia +7 more
core +2 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Metallic nanoparticles made in flow and their catalytic applications in organic synthesis
Nanotechnology Reviews, 2014 This paper reviews recent developments on the synthesis of noble metal nanoparticles in micro and millifluidic devices and their catalytic application in organic flow synthesis.
Shahbazali Elnaz +3 more
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Solvent Resistant O2 Sensor Integrated in Pressured Flow Reactors
Proceedings, 2019 In this contribution we present an optical oxygen sensor that can easily be integrated into continuous flow reactors. The sensors are pressure resistant to up to 8 bars and are able to continuously measure oxygen for several hours in organic solvents ...
Philipp Sulzer, René Lebl, Torsten Mayr
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
SN Applied Sciences, 2021 This work presents an innovative silica-layer coated capillary with comparison study of the silica-layer coated capillary and the fused-silica capillary for the separation of seven phenolic acids viz.
Pattamaporn Hemwech +6 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source