Results 61 to 70 of about 2,034,998 (303)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A data–driven sensibility tool for flow control based on resolvent analysis

Results in Engineering
This study presents a novel application of data-driven resolvent analysis algorithm for flow control. The objective is to identify key coherent structures connected to regions of the flow that are highly sensitive to structural changes.
E. Lazpita, J. Garicano-Mena, G. Paniagua, S. Le Clainche, E. Valero   +4 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Control-Flow Semantics for Assembly-Level Data-Flow Graphs [PDF]

, 2006
As part of a larger project, we have built a declarative assembly language that enables us to specify multiple code paths to compute particular quantities, giving the instruction scheduler more flexibility in balancing execution resources for superscalar execution.
Wolfram Kahl, Christopher K. Anand, Jacques Carette   +2 more
openaire   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Data regarding the computational fluid dynamics simulations of an airfoil with plasma actuator in unsteady flow

Data in Brief, 2020
The data regard the analysis reported in the research article “Influence of actuation parameters of multi-DBD plasma actuators on the static and dynamic behavior of an airfoil in unsteady flow” [1].
Maria Grazia De Giorgi, Valentina Motta, Antonio Suma   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Evaluating Convolutional Autoencoders for Anomaly Detection on Space-Filling Curve-Transformed Control Flow Data

IEEE Access
Microcontrollers are increasingly targeted by cyber threats, requiring robust and adaptive security mechanisms. This work presents a novel anomaly detection pipeline that transforms microcontroller program control-flow data into Hilbert space-filling ...
Pranav Gangwani, Alexander Perez-Pons, Gabriel Alvarez, Sebastian De La Cruz   +3 more
doaj   +1 more source

A data-driven Reduced Order Method for parametric optimal blood flow control: application to coronary bypass graft [PDF]

, 2022
Caterina Balzotti, Pierfrancesco Siena, Michele Girfoglio, Annalisa Quaini, Gianluigi Rozza   +4 more
openalex   +1 more source