Results 141 to 150 of about 3,078,576 (239)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ImProver: Agent-Based Automated Proof Optimization

Large language models (LLMs) have been used to generate formal proofs of mathematical theorems in proofs assistants such as Lean. However, we often want to optimize a formal proof with respect to various criteria, depending on its downstream use.
Welleck, Sean, Tetali, Prasad, Ahuja, Riyaz, Avigad, Jeremy   +3 more
core  

An autonomous agentic workflow for clinical detection of cognitive concerns using large language models. [PDF]

NPJ Digit Med
Tian J, Fard P, Cagan C, Rezaii N, Rocha RB, Wang L, Junior VM, Blacker D, Haas JS, Patel CJ, Murphy SN, Moura LMVR, Estiri H.   +12 more
europepmc   +1 more source

Comparative Study between a Copolymer Based on Oleic Acid and Its Nanohybrid for Improving the Cold Flow Properties of Diesel Fuel. [PDF]

ACS Omega, 2023
El-Segaey AA, El-Azabawy RE, A Mohammed H, Al-Shafey HI, Kamal RS.   +4 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Early Functional Recovery Trajectories After Severe Traumatic Brain Injury: A Secondary Analysis of the TBIMS National Database. [PDF]

Brain Sci
Calderone A, Bonanno L, Rifici C, Calabrò RS.   +3 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Functional recovery of islet β cells in human type 2 diabetes: Transcriptome signatures unveil therapeutic approaches. [PDF]

Sci Adv
Suleiman M, Sawatani T, Tesi M, Yi X, Papadopoulou T, Rufer C, Lytrivi M, Bosi E, Burdet F, Fantuzzi F, De Luca C, Sebastiani G, Saponaro C, Pugliese LA, Del Guerra S, Pocai A, De Simone P, Ghinolfi D, Boggi U, Kessler C, Grieco GE, Fignani D, Kerr-Conte J, Pattou F, Nacher M, Montanya E, Mourad N, Buemi A, Citi V, Martelli A, Benedetti G, Calderone V, Rossi L, Paolicchi A, Cardarelli F, Dotta F, Eizirik DL, Ibberson M, Marchetti P, Cnop M, Marselli L.   +40 more
europepmc   +1 more source

Resource utilization of medical waste under COVID-19: Waste mask used as crude oil fluidity improver. [PDF]

J Clean Prod, 2022
Wang P, Gu X, Xue M, Li Y, Dong S, Chen G, Zhang J.   +6 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source