Results 151 to 160 of about 3,078,576 (239)

Real-world effectiveness and safety of tonic motor activation therapy for refractory restless legs syndrome: 90-day outcomes from the THRIVE prospective observational study. [PDF]

Sleep
Singh H, Buchfuhrer MJ, Ojile J, Roy A, Thomas RJ, Bogan RK, Aggarwal A, Preciado J, Swartz KJ, Charlesworth JD.   +9 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Establish input parameters for maximizing carbon neutral concoction in CI engine to achieve optimal engine out responses for hybrid operation. [PDF]

Sci Rep
Muniyappan S, Krishnaiah R.
europepmc   +1 more source

Extra heavy crude oil viscosity and surface tension behavior using a flow enhancer and water at different temperatures conditions. [PDF]

Heliyon, 2023
Lam-Maldonado M, Aranda-Jiménez YG, Arvizu-Sanchez E, Melo-Banda JA, Díaz-Zavala NP, Pérez-Sánchez JF, Suarez-Dominguez EJ.   +6 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The Role of Abatacept on Inflammation and Fibrosis in Hypochlorous Acid-Induced Fibrosis Mice. [PDF]

Int J Rheum Dis
Dai B, Meng M, Chen W, Zhou J, Meng Q, Ding L, Xie S, Bao D, Li X, Zhao L, Huang T, Lv C, Luo H, Liu S, Zhu H.   +14 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Growing hulled wheat and old bread wheat genotypes in non-marginal environments: agronomic, qualitative, and safety insights. [PDF]

Front Plant Sci
Sardella C, Vanara F, Scapino M, Scarpino V, Pedrazzani C, Dall'Asta C, Blandino M.   +6 more
europepmc   +1 more source

Manufacturing of Corrosion Inhibitors and Flow Improvers from Recycling of Waste at Hail City, Saudi Arabia: Physicochemical and Electrochemical Studies on Steel in Petroleum Industries. [PDF]

ACS Omega, 2023
Abdel-Hameed R, AlElaimi M, Qureshi MT, Aleid GM, Al-Shafey HI, Alshammary F, Huwaimel B, Aljuhani EH, Al-Bonayan AM, Al-Mhyawi S.   +9 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source