Results 41 to 50 of about 335,553 (312)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Loop Leaping with Closures (proof appendix for conference submission) [PDF]
, 2012 Loop leaping is the colloquial name given to a form of program analysis in which summaries are derived for nested loops starting from the innermost loop and proceeding in a bottom-up fashion considering one more loop at a time.
Brauer, Jorg +3 more
core
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
, 2022 Relationship between pump flow, mock ventricular flow, and total mean flow for the Inspired Therapeutics NeoMate System and inflow (24F) and outflow (16F) cannula in a dynamic mock flow loop model over a range of pump speeds for Systems A and B.
Mark S. Slaughter (8038565) +8 more
core +1 more source
Geochemistry, Geophysics, GeosystemsTracking methane transport becomes more complicated in the deep ocean where seafloor release of methane gas bubbles occurs at the high pressures and low temperatures conducive to hydrate formation on bubble surfaces.
Alexandra M. Padilla, William F. Waite
doaj +1 more source
Design of dust sampler based on closed-loop flow control
Gong-kuang zidonghua, 2015 In view of problem of big sampling error of dust sampler based on open-loop control, a dust sampler based on closed-loop flow control was designed. The sampler uses micro gas flow sensor to collect flow, adopts incremental PID control algorithm with die ...
WU Fuxiang
doaj +1 more source
Applied Sciences, 2020 This study focused on gas/Newtonian and gas/non-Newtonian two-phase horizontal fluid flow behavior by analyzing their flow regime identification and flow structural analysis on a horizontal flow loop apparatus.
Munzarin Morshed +3 more
doaj +1 more source
Flow Volume Loops in Patients With Goiters
Annals of Surgery, 1992 Plain radiology is the standard means of assessing upper airway obstruction in patients with goiters. Flow volume loop curves will provide additional information, because they allow a quantitative assessment of airflow dynamics in the respiratory cycle. Fifty-one patients had flow volume loops performed before and after thyroidectomy.
J G, Geraghty +3 more
openaire +3 more sources
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source