Results 151 to 160 of about 1,043,068 (316)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Feature extraction via heat flow analogy

, 2009
Feature extraction is an important field of image processing and computer vision. Features can be classified as low-level and high-level. Low-level features do not give shape information of the objects, where the popular low-level feature ...
Direkoğlu, Cem
core  

Cerebral Blood Flow Pattern Changes in Unilateral Sudden Sensorineural Hearing Loss. [PDF]

Front Neurosci, 2022
Chen Y, Li H, Liu B, Gao W, Yang A, Lv K, Xia H, Zhang W, Yu H, Liu J, Liu X, Wang Y, Han H, Ma G.   +13 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Abnormal flow pattern of low wall shear stress and high oscillatory shear index in spontaneous vertebral artery dissection with vertebral artery hypoplasia. [PDF]

Front Neurosci, 2023
Bao J, Gan X, Feng W, Li Y, Qiu Y, Zhou M, Guo J, He L.   +7 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Pressure drop of different flow pattern in multiphase flow system [PDF]

, 2015
Multiphase flow is not an old issue to be discussed. Pressure drop and heat transfer under multiphase flow are very complicated to predict. Lots of empirical correlations have been made to predict pressure drop in pipelines under multiphase condition ...
Mohammad Hafizezazmi, Ajamain
core  

Flow pattern analysis in a highly stenotic patient-specific carotid bifurcation model using a turbulence model

, 2015
The aim of this study is to investigate the blood flow pattern in carotid bifurcation with a high degree of luminal stenosis, combining in vivo magnetic resonance imaging (MRI) and computational fluid dynamics (CFD).
Soloperto, G., Li, Z.Y., Xu, X. Y., Tan, F.P.P., Wood, N. B., Gillard, J. H.   +5 more
core   +1 more source

Virtual Water Flow Pattern in the Yellow River Basin, China: An Analysis Based on a Multiregional Input-Output Model. [PDF]

Int J Environ Res Public Health, 2022
Liu X, Xiong R, Guo P, Nie L, Shi Q, Li W, Cui J.   +6 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source