Results 131 to 140 of about 3,049,820 (297)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Numerical Simulation on the Flow Pattern of a Gas-Liquid Two-Phase Swirl Flow. [PDF]

ACS Omega, 2022
Rao Y, Liu Z, Wang S, Li L.
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Flow Pattern Identification of Oil-Water Two-Phase Flow Based on SVM Using Ultrasonic Testing Method. [PDF]

Sensors (Basel), 2022
Su Q, Li J, Liu Z.
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

SIMULATIONS OF FLOW PATTERNS IN SILOS WITH A CELLULAR AUTOMATON: PART 2

TASK Quarterly, 2005
An improved cellular automaton has been used to calculate the kinematics of noncohesive granular materials during confined flow in mass and funnel flow model silos.
JAN KOZICKI, JACEK TEJCHMAN
doaj  

Study on the Improvement of Flow Pattern of Rest Pools of Vertical Slot Fishway

Renmin Zhujiang, 2020
Rest pools provide a rest place for migratory fish to swim upstream,so whether its flow pattern is reasonable or not directly affects the upstream efficiency of fish.Based on the design principle of the mainstream centered in the pool,this paper builds a
JIANG Hui, RONG Guiwen, SUN Shuangke, ZHENG Tiegang, MENG Han   +4 more
doaj  

Information Flow Pattern in Early Mild Cognitive Impairment Patients. [PDF]

Front Neurol, 2021
He H, Ding S, Jiang C, Wang Y, Luo Q, Wang Y, Alzheimer's Disease Neuroimaging Initiative.   +6 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Wax Deposition Law under a Gas-Liquid Bubbly Flow Pattern. [PDF]

ACS Omega, 2021
Yu X, Gao Y, Cai D, Yao W, Zhou Y, Su Y, Liu K.   +6 more
europepmc   +1 more source