Results 121 to 130 of about 3,049,820 (297)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Gas-Liquid Flow Pattern and Hydrate Risk in Wellbore during the Deep-Water Gas-Well Cleanup Process. [PDF]

ACS Omega, 2023
Chen D, Sun Z.
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Optimizing Infusate Flow Patterns for Minimizing Vein Wall Trauma: An Exploratory Study with a Modified off-Axis Catheter Tip Opening

Therapeutics and Clinical Risk Management
Amit Bahl,1 S Matthew Gibson,2 Alexis Walton3 1Department of Emergency Medicine, Oakland University William Beaumont School of Medicine, Rochester, MI, USA; 2Vascular Access Consulting, Henderson, KY, USA; 3Department of Emergency Medicine, Corewell ...
Bahl A, Gibson SM, Walton A
doaj  

Flow Pattern Study and Pressure Drop Prediction of Two-Phase Boiling Process in Different Surface Wettability Microchannel. [PDF]

Micromachines (Basel), 2023
Zhang Y, Wu H, Zhang L, Yang Y, Niu X, Zeng Z, Shu B.   +6 more
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Flow pattern-dependent mitochondrial dynamics regulates the metabolic profile and inflammatory state of endothelial cells. [PDF]

JCI Insight, 2022
Hong SG, Shin J, Choi SY, Powers JC, Meister BM, Sayoc J, Son JS, Tierney R, Recchia FA, Brown MD, Yang X, Park JY.   +11 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A Unified Drift–Flux Framework for Predictive Analysis of Flow Patterns and Void Fractions in Vertical Gas Lift Systems

Fluids
This study utilizes the drift–flux model to develop a new flow pattern map designed to facilitate an accurate estimation of gas void fraction (αg) in vertical upward flow. The map is parameterized by mixture velocity (um) and gas volumetric quality (βg),
Omid Heydari, Sohrab Zendehboudi, Stephen Butt   +2 more
doaj   +1 more source

Numerical Simulation of the Flow Pattern of Spiral Annular Flow with a Guide Strip by Spiral On-Way. [PDF]

ACS Omega, 2022
Rao Y, Wang S, Li L.
europepmc   +1 more source