Results 161 to 170 of about 2,404,496 (308)

Utility of Blood Flow/Resistance Index Ratio (Q_x) as a Marker of Stenosis and Future Thrombotic Events in Native Arteriovenous Fistulas. [PDF]

Front Surg, 2020
Colombo A, Provenzano M, Rivoli L, Donato C, Capria M, Leonardi G, Chiarella S, Andreucci M, Fuiano G, Bolignano D, Coppolino G.   +10 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Method to simulate distal flow resistance in coronary arteries in 3D printed patient specific coronary models. [PDF]

3D Print Med, 2020
Sommer KN, Iyer V, Kumamaru KK, Rava RA, Ionita CN.   +4 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

On the Homogenization of Geological Fissured Systems With Curved non-periodic Cracks

, 2013
We analyze the steady fluid flow in a porous medium containing a network of thin fissures i.e. width $\mathcal{O}(\epsilon)$, where all the cracks are generated by the rigid translation of a continuous piecewise $C^{1}$ functions in a fixed direction ...
Morales, Fernando A.
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

In Vitro Evaluation of the Potential Interactions of Zearalenone-14-sulfate and Zearalenone-14-glucuronide with Human Cytochrome P450 Enzymes, Organic Anion Transporting Polypeptides, and ATP-Binding Cassette Multidrug Transporters

ACS Omega
Ágnes Telbisz, Hana Kaci, Éva Bakos, Zoltán Nagymihály, Eszter B. Both, Nándor Lambert, Csilla Özvegy-Laczka, Miklós Poór   +7 more
doaj   +1 more source

Flow through very porous inclined screens [PDF]

The steady, inviscid flow through and around a screen inclined at a uniform angle to the incoming flow was investigated. For a screen placed in an infinite flow field, an asymptotic analysis for small resistance coefficients was performed, and the ...
Durbin, P. A., Muramoto, K. K.
core   +1 more source

Synergistic Effects of Biomimetic Structures on Heat Transfer Enhancement and Flow Resistance Reduction. [PDF]

Biomimetics (Basel)
Wang K, Shi Y, Chen J, Dai Y.
europepmc   +1 more source