Results 151 to 160 of about 2,404,496 (308)

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Scientific Machine Learning of Flow Resistance Using Universal Shallow Water Equations With Differentiable Programming

Water Resources Research
Shallow water equations (SWEs) are the backbone of most hydrodynamics models for flood prediction, river engineering, and many other water resources applications.
Xiaofeng Liu, Yalan Song
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A Unified Flow Resistance Formula for Open‐Channels With Natural and Engineered Submerged Obstacles

Water Resources Research
Stream obstacles, naturally formed like boulders or engineered like weirs, are the major source of flow resistance; however, to quantify their flow resistance, a resistance formula needs to be selected in accordance with the specific obstacle type, that ...
Xingyu Chen, Tao Wang, Jiamei Wang, Hongbo Ma, Marwan A. Hassan, Xudong Fu   +5 more
doaj   +1 more source

Computational fluid dynamics model and flow resistance characteristics of Jatropha curcas L xylem vessel. [PDF]

Sci Rep, 2020
Xu T, Zhang L, Li Z.
europepmc   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Effect of nonsymmetrical flow resistance upon orifice impedance resistance [PDF]

A nonreactive orifice in an infinite baffle is analyzed. The pressure difference delta across the orifice varies sinusoidally with amplitude 1.0 and average value -P.
Compton, K. J., Posey, J. W.
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Study on Flow Resistance of Discharge Valve Cover of Subsurface Pump in Polymer Flooding Well

Shiyou jixie, 2019
During the oil production process under polymer flooding, the flow resistance of the discharge valve cover of subsurface pump is usually significant owing to the high viscosity of the fluid, which presents a challenge to the load analysis and ...
Lin Kai, Shu Fangqi
doaj