Results 141 to 150 of about 8,082,222 (392)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
New Method for Kinematic Analysis of Gear Trains-Signal Flow Chart Method
Jixie chuandong, 1995 Signal flow chart and its simplified rule are introduced in this paper. Basis structure method for signal flow chart of gear train are discussed. Essential step for kinematic analysis of double gear train to apply signal flow chart method are studied ...
Yang Xinghai
doaj
Fiscal and Monetary Policies in a Keynesian Stock-Flow Consistent Model [PDF]
Following the New Classical Macroeconomics and the New Keynesian Macroeconomics, the independence of central banks significantly increased after 1990, which could preclude the coordination between the fiscal and the monetary policies. The purpose of this
Edwin Le Heron
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
What do deficits tell us about debt? Empirical evidence on creative accounting with fiscal rules in the EU [PDF]
Fiscal rules, such as the excessive deficit procedure and the stability and growth pact (SGP), aim at constraining government behavior. Milesi-Ferretti (2003) develops a model in which governments circumvent such rules by reverting to creative accounting.
von Hagen, Jürgen, Wolff, Guntram B.
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
On flow rules in plastic deformation
, 1991 Summary: The purpose of the present paper is to compare some consquences of the classical flow-rule of plasticity due to Levy and Mises with those of the flow equation recently proposed by \textit{R. N. Dubey} and \textit{S. Bedi} [Proc. Adv. Plast., pp. 291-295 (1989)].
Dubey, R., Bedi, S.
openaire +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Tongxin xuebaoTo address the issue of slow end-to-end link establishment in software defined network (SDN) controllers, a novel dual-phase optimization method named ZHPro, based on zero-hop transmission and parallel flow rule deployment, was proposed.
ZHAO Baokang, LI Yikun, YANG Yu
doaj
A curve shortening flow rule for closed embedded plane curves with a prescribed rate of change in enclosed area. [PDF]
Proc Math Phys Eng Sci, 2016 Dallaston MC, McCue SW.
europepmc +1 more source