Results 141 to 150 of about 295,706 (263)
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Information-Driven Rule Reduction in Belief Rule Bases for Complex System Modeling. [PDF]
Entropy (Basel)Liu X, Huang H, Li Y, Xia Z, Zhao S.
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
A knowledge graph framework for digital twins of chemical processes. [PDF]
Nat Chem EngZhang S, Zhang J, Lapkin AA.
europepmc +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Self-supervised Deep Learning for Denoising in Ultrasound Microvascular Imaging. [PDF]
Biomed Signal Process ControlHuang L +17 more
europepmc +1 more source
A Derivation of the Associated Flow Rule
A Derivation of the Associated Flow RuleThe associated flow rule in the traditional theory of plasticity has been recently adopted even in the plastic constitutive equations with the elastic-plastic transition. The proofs of this rule in the past, however, are confined to the classical idealization of elastoplastic continuum to ignore the elastic-plastic transition and the alteration in an ...
openaire
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Non-invasive estimation of coronary resistance and compliance: Prospective diagnostic study vs. angiography. [PDF]
Am Heart J PlusLee BK +4 more
europepmc +1 more source