Results 81 to 90 of about 161,061 (357)

Modelling and solving train scheduling problems under capacity constraints [PDF]

, 2008
Many large coal mining operations in Australia rely heavily on the rail network to transport coal from mines to coal terminals at ports for shipment. Over the last few years, due to the fast growing demand, the coal rail network is becoming one of the ...
Liu, Shi-Qiang
core   +1 more source

Comparative simulation study of production scheduling in the hybrid and the parallel flow [PDF]

, 2017
Scheduling is one of the most important decisions in production control. An approach is proposed for supporting users to solve scheduling problems, by choosing the combination of physical manufacturing system configuration and the material handling ...
Al, Aneke, Arrais, Cao, Cao, Carvalho, Cheng, Diering, Haouari, Henning, Huang, Huang, Jain, Jain, Janiak, Johnson, Kujawinska, Kujawińska, Lenstra, Linn, Madureira, Madureira, Madureira, Magalhães, McPherson, Mehta, Muhlemann, Naderi, Nowicki, Ovacik, Ovacik, Pinto, Quadt, Ribeiro, Ruiz, Ruiz, Sabuncuoglu, Sun, Szelke, Vairaktarakis, Varela, Varela, Varela, Vieira, Vieira, Vieira, Vieira, Yamamoto, Zhang   +48 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

New efficient constructive heuristics for the hybrid flowshop to minimise makespan: A computational evaluation of heuristics [PDF]

, 2018
This paper addresses the hybrid flow shop scheduling problem to minimise makespan, a well-known scheduling problem for which many constructive heuristics have been proposed in the literature. Nevertheless, the state of the art is not clear due to partial
Fernández-Viagas Escudero, Víctor, Framiñán Torres, José Manuel, Molina Pariente, José Manuel   +2 more
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The Effectiveness of Genetic Algorithm, And the CDS Method In Solving Flowshop Scheduling Problems [PDF]

E3S Web of Conferences
Flow shop scheduling problem is considered NP-hard for m machines and n jobs. For such NP-hard combinatorial optimization problems, heuristics play a major role in searching for near-optimal solutions. In this paper we used Genetic Algorithm, and the CDS
Prassetiyo Hendro, Heryati Firda
doaj   +1 more source

Efficiency of the solution representations for the hybrid flow shop scheduling problem with makespan objective [PDF]

, 2019
In this paper we address the classical hybrid flow shop scheduling problem with makespan objective. As this problem is known to be NP-hard and a very common layout in real-life manufacturing scenarios, many studies have been proposed in the literature to
Fernández-Viagas Escudero, Víctor, Framiñán Torres, José Manuel, Pérez González, Paz   +2 more
core  

Evolving control rules for a dual-constrained job scheduling scenario [PDF]

, 2016
Dispatching rules are often used for scheduling in semiconductor manufacturing due to the complexity and stochasticity of the problem. In the past, simulation-based Genetic Programming has been shown to be a powerful tool to automate the time-consuming ...
Branke, Jürgen, Groves, Matthew J., Hildebrandt, Torsten   +2 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Improve Algoritma Hodgson Untuk Meminimasi Jumlah Job Terlambat Pada Penjadwalan Flow shop

Jurnal Teknik Industri, 2018
Since Johnson published a paper in 1954, the problem of job scheduling has received the attention of hundreds of practitioners and researchers, as one of the most studied topics in Operation research.
Dian Setiya Widodo
doaj   +1 more source