Results 61 to 70 of about 488,823 (305)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Letter from the Editor

, 2012
In the act of pondering the majesty of God’s Creation, I never tire of observing the slide of Autumn as it nestles into Winter and the beauty of the snow that follows.
Belcher, E. Christina
core   +1 more source

DevOps is Bigger than IT: Driving Digital Transformation in Libraries [PDF]

, 2020
The DevOps movement represents a paradigm shift in software development, but there are misconceptions about what it really means. It’s much more nuanced than simply adding a DevOps engineer to your team or asking systems administrators and developers to ...
Snapp, Mary Beth, Vinopal, Jennifer
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Calculation of lubricant flow in the slide bearing of the aviation engine reducer

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение, 2019
A method has been developed for calculating the pressure distribution in a cylindrical slide bearing. We present the process of designing a heavy-duty slide bearing as a component of the reduction gearbox of a bypass turbojet engine as the object of our ...
M. V. Siluyanova, A. О. Fertikov
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Nano-scale superhydrophobicity: suppression of protein adsorption and promotion of flow-induced detachment [PDF]

, 2008
Wall adsorption is a common problem in microfluidic devices, particularly when proteins are used. Here we show how superhydrophobic surfaces can be used to reduce protein adsorption and to promote desorption.
A. J. de Mello, Ainslie, Asuri, Bearinger, Callies, Callow, Cassie, Chen, Choi, Furstner, G. McHale, Genzer, Huber, Hyong-Seok Kim, M. I. Newton, Ma, Mandal, N. J. Shirtcliffe, Ou, P. Roach, Pallandre, Prime, Roach, Roach, Roach, Shirtcliffe, Shirtcliffe, Shirtcliffe, Sun, Taylor, Toes, Truesdell, Vasconcelos, Vroman, Wen, Wenzel, Wu, Y. Koc, Zhang   +38 more
core   +1 more source

UAV and field survey investigation of a landslide triggered debris flow and dam formation in Eastern Carpathians

Frontiers in Earth Science
In the May–August period of 2010, major heavy rains impacted the Eastern Carpathians (Northeastern Romania), leading to flash floods and triggering numerous landslides.
Alin Mihu-Pintilie, Cristian Constantin Stoleriu, Andrei Urzică, Andrei Urzică   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Experiments on seepage-triggered cliff landslides using cohesive wet sand

Progress in Earth and Planetary Science, 2022
Unsaturated wet sand possesses capillary cohesion that is lost when it becomes saturated. Thus, it can form a cliff, but a slide may be triggered upon saturation.
Fumi Shibuya, Ikuro Sumita
doaj   +1 more source