Results 31 to 40 of about 289,315 (267)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Aerodynamic Characteristics of High-speed Train Pantographs Based on Jet Flow Control [PDF]
Journal of Applied Fluid MechanicsThe pantograph is a critical instrument that significantly affects the aerodynamics of high-speed trains, posing a considerable challenge to the energy conservation and environmental protection of trains.
S. Huang +5 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Clinical Ophthalmology, 2012 Yuki Hashimoto,1 Wataru Saito,1,2 Shohei Mori,1 Michiyuki Saito,1 Susumu Ishida1,21Department of Ophthalmology, 2Department of Ocular Circulation and Metabolism, Hokkaido University Graduate School of Medicine, Sapporo, JapanPurpose: The precise ...
Hashimoto Y +4 more
doaj
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Flow Velocity Profile of Micro Counter-Current Flows
Analytical Sciences, 2007 Flow velocity profiles of micro counter-current flow of aqueous and butylacetate phases in a microchannel having a width of 100 microm were measured by micro particle image velocimetry. In order to analyze the hydrodynamic characteristics of the counter-current flow, we derived a simple analytical model for the velocity profile.
Arata, Aota +5 more
openaire +3 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Effect of Flow Velocity on Laminar Flow in Microfluidic Chips
Micromachines, 2023 Gel fibers prepared based on microfluidic laminar flow technology have important research value in constructing biomimetic scaffolds and tissue engineering.
Chuang Wu +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source