Results 71 to 80 of about 31,225 (293)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Hygroscopicity issues in powder and grain technology [PDF]
, 2018 The effect of hygroscopicity on flowability of powders and bulk solids with applications in the packaging industry is experimentally and numerically investigated. Firstly, four granular materials are tested at different water contents to study the impact
Rodríguez Ferran, Antonio +2 more
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
IOP Conference Series: Materials Science and Engineering, 2018 The paper considers principal factors influencing fluid properties of cement powder. Analysis with a correlation regression method has shown that a variable factor which has not been previously quantitatively evaluated, influences the fluid properties.
L D Shahova +2 more
openaire +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Analysis of the effect of cohesion and gravity on the bulk behaviour of powders using Discrete Element Method [PDF]
, 2004 Computer simulations using Distinct Element Method have been carried out to analyse the bulk behaviour of a polydisperse assembly of glass beads. For this purpose an assembly made of 3000 spheres were generated to which the mechanical properties of glass
Antony, SJ +2 more
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Three-Dimensional Printable Concrete by an Ultra-Thin Nozzle and Fully Sealed Extrusion
BuildingsDue to the molding-free property and dry shrinkage of extrusion-based three-dimensional printable concrete (3DPC), the precision issues of 3DPC have not been solved effectively. One of the viable solutions for 3DPC precision improvement is to print using
Jing Shen +5 more
doaj +1 more source
Revista Brasileira de Engenharia Agrícola e Ambiental, 2001 Neste trabalho, foram caracterizados seis tipos de material inerte, utilizados na secagem de polpa de frutas em leito de jorro. Determinou-se o ângulo de repouso das partículas, com e sem adição de água e de polpa de diversas frutas tropicais ...
Maria de F. D. de Medeiros +6 more
doaj +1 more source