Results 71 to 80 of about 30,676 (298)

The effect of nicotinamide adenine dinucleotide phosphate oxidase 4 on migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis

Arthritis Research & Therapy, 2020
Background Reactive oxygen species (ROS) regulate the migration and invasion of fibroblast-like synoviocytes (FLS), which are key effector cells in rheumatoid arthritis (RA) pathogenesis.
Ha-Reum Lee, Su-Jin Yoo, Jinhyun Kim, In Seol Yoo, Chan Keol Park, Seong Wook Kang   +5 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Acylcarnitine enrichment as a characteristic of rheumatoid arthritis fibroblast-like synoviocyte metabolic fingerprint

Journal of Translational Autoimmunity
Objective: In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) alter their metabolism to support their activation. We aimed to analyse the full spectrum of metabolic alterations associated with RA by performing untargeted metabolomics in RA ...
Georgios K. Vasileiadis, Yuan Zhang, Marion Laudette, Tahzeeb Fatima, Anna-Karin Hultgård Ekwall, Reshmi Sureshkumar, Ronald van Vollenhoven, Jon Lampa, Bjorn Gudbjornsson, Espen A. Haavardsholm, Dan Nordström, Gerdur Gröndal, Kim Hørslev-Petersen, Kristina Lend, Merete L. Hetland, Michael Nurmohamed, Mikkel Østergaard, Till Uhlig, Tuulikki Sokka-Isler, Anna Rudin, Jan Borén, Monica Guma, Cristina Maglio   +22 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Soluble factors released from fibroblast-like synoviocytes of JIA patients with future extended course can condition persistent JIA synovial fibroblasts for increased IL-6 production

Arthritis Research & Therapy
Background Juvenile Idiopathic Arthritis (JIA) includes a subset of oligoarticular patients who later extend to a polyarticular course (extended-to-be, ETB), resulting in worse outcomes. Predictors of extension remain poorly defined.
Megan M. Simonds, Lina Al-Jaberi, Hermine I. Brunner, AnneMarie C. Brescia   +3 more
doaj   +1 more source

Engineering stable topography in dense bio-mimetic 3D collagen scaffolds [PDF]

European Cells & Materials, 2012
Topographic features are well known to influence cell behaviour and can provide a powerful tool for engineering complex, functional tissues. This study aimed to investigate the mechanisms of formation of a stable micro-topography on plastic compressed ...
T Alekseeva, E Hadjipanayi, EA Abou Neel, RA Brown   +3 more
doaj  

Hypoxia-induced miR-191-C/EBPβ signaling regulates cell proliferation and apoptosis of fibroblast-like synoviocytes from patients with rheumatoid arthritis

Arthritis Research & Therapy, 2019
Background Hypoxia plays an important role in the proliferation of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS), leading to pathology of RA.
Shanshan Yu, Ying Lu, Ming Zong, Qi Tan, Lieying Fan   +4 more
doaj   +1 more source

The efficacy of FLS for hip fractures [PDF]

【目的】近年、二次骨折予防のために骨折リエゾンサービス（以下FLS）の導入が推進されている。当院では2021年から入院した脆弱性骨折症例に対し、FLSによる介入を開始している。FLSは多職種でチームを構築し薬物療法と転倒予防を行った。今回われわれは、大腿骨近位部骨折におけるFLSの効果を検討した。 【対象と方法】対象は当院で手術を行った大腿骨近位部骨折418例。年齢は平均84.8才、性別は男性93例、女性325例。このうちFLS導入前の2017年の症例219例をBefore群 ...
小椋,隆宏, 前川,尚大, 中田,旭彦, 玉置,康之, 岩本,健太郎, 田中,康之, 田中,慶尚, 古川,剛, 武本,直樹, 小竹,広朗   +9 more
core  

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

Biosurveillance of avian orthoavulavirus 1 in multiple avian species in Pakistan from 2011 to 2021

Open Veterinary Journal
Background: Newcastle disease (ND) is a highly infectious disease of multiple avian species worldwide. In Pakistan, repeated ND outbreaks have presented substantial challenges to the poultry sector.
Abdul Wajid, Abeera Abid, Maria Malik, Andleeb Batool, Quratulain Maqsood, Rameez Ishaq, Asma Yousafzai, Ghulam Rasool, Ibrahim Eldaghayes   +8 more
doaj   +1 more source